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本文引用的文献

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Visualizing protein-nucleic acid interactions on a large scale with the scanning force microscope.利用扫描力显微镜大规模可视化蛋白质-核酸相互作用。
Annu Rev Biophys Biomol Struct. 1996;25:395-429. doi: 10.1146/annurev.bb.25.060196.002143.
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A trans-platinum complex showing higher antitumor activity than the cis congeners.一种比顺式同类物显示出更高抗肿瘤活性的反式铂配合物。
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Atomic force microscopy of DNA in aqueous solutions.水溶液中DNA的原子力显微镜观察。
Nucleic Acids Res. 1993 Feb 11;21(3):505-12. doi: 10.1093/nar/21.3.505.
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Scanning force microscopy of circular and linear plasmid DNA spread on mica with a quaternary ammonium salt.用季铵盐在云母上展开的环状和线性质粒DNA的扫描力显微镜观察。
Nucleic Acids Res. 1993 Dec 25;21(25):6004-9. doi: 10.1093/nar/21.25.6004.
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Identification of DNA--cisplatin adducts in a blind trial of in situ scanning tunneling microscopy.
Nucleic Acids Res. 1993 Dec 25;21(25):5896-900. doi: 10.1093/nar/21.25.5896.
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Recent advances in atomic force microscopy of DNA.DNA原子力显微镜技术的最新进展。
Scanning. 1993 Sep-Oct;15(5):296-9. doi: 10.1002/sca.4950150509.
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Direct observation of enzyme activity with the atomic force microscope.用原子力显微镜直接观察酶活性
Science. 1994 Sep 9;265(5178):1577-9. doi: 10.1126/science.8079171.
9
Bending and straightening of DNA induced by the same ligand: characterization with the atomic force microscope.同一配体诱导的DNA弯曲与伸直：用原子力显微镜进行表征
Biochemistry. 1994 Jul 19;33(28):8436-41. doi: 10.1021/bi00194a007.
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Stretched DNA structures observed with atomic force microscopy.用原子力显微镜观察到的拉伸DNA结构。
Nucleic Acids Res. 1994 Oct 11;22(20):4224-8. doi: 10.1093/nar/22.20.4224.

利用原子力显微镜研究DNA与顺铂及其他钯（II）和铂（II）配合物的相互作用。

Study of the interaction of DNA with cisplatin and other Pd(II) and Pt(II) complexes by atomic force microscopy.

作者信息

Onoa G B, Cervantes G, Moreno V, Prieto M J

机构信息

Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028-Barcelona, Spain.

出版信息

Nucleic Acids Res. 1998 Mar 15;26(6):1473-80. doi: 10.1093/nar/26.6.1473.

DOI:10.1093/nar/26.6.1473
PMID:9490794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC147433/
Abstract

Modifications in the structure of a 260 bp DNA (hlyM) fragment from Escherichia coli caused by interaction with Pd(II) and Pt(II) complexes were studied. Cisplatin and transplatin [cis- and trans-PtCl2(NH3)2 respectively], Pt2Cl2(Spym)4 (Spym = 2-mercaptopyrimidine anion), Pd-famotidine and Pt-famotidine were incubated with DNA for 24 h at 37 degrees C and then observed with an atomic force microscope. Atomic force microscopy (AFM) provides the opportunity for nanometer resolution in research on the interaction between nucleic acids and metal complexes. The complexes induced noticeable changes in DNA topography according to their different characteristics and structure. In the case of cisplatin a shortening in DNA strands was observed. Transplatin and Pt2Cl2(Spym)4 caused shortening and compaction, whilst an aggregation of two strands was observed for the Pt-famotidine compound but not for the Pd-famotidine compound or the metal-free famotidine.

摘要

研究了来自大肠杆菌的260 bp DNA（hlyM）片段与钯（II）和铂（II）配合物相互作用导致的结构变化。顺铂和反铂（分别为顺式和反式 - PtCl2(NH3)2）、Pt2Cl2(Spym)4（Spym = 2 - 巯基嘧啶阴离子）、钯 - 法莫替丁和铂 - 法莫替丁在37℃下与DNA孵育24小时，然后用原子力显微镜观察。原子力显微镜（AFM）为研究核酸与金属配合物之间的相互作用提供了纳米分辨率的机会。根据其不同的特性和结构，这些配合物在DNA拓扑结构上引起了明显变化。对于顺铂，观察到DNA链缩短。反铂和Pt2Cl2(Spym)4导致缩短和压缩，而对于铂 - 法莫替丁化合物观察到两条链聚集，而钯 - 法莫替丁化合物或无金属的法莫替丁则未观察到。