费城染色体阴性慢性髓性白血病患者出现T细胞表型的淋巴细胞危象。

Lymphoid crisis with T-cell phenotypes in a patient with Philadelphia chromosome negative chronic myeloid leukaemia.

作者信息

Soda H, Kuriyama K, Tomonaga M, Yao E, Amenomori T, Yoshida Y, Matsuo T, Jinnai I, Sadamori N, Ichimaru M

出版信息

Br J Haematol. 1985 Apr;59(4):671-9. doi: 10.1111/j.1365-2141.1985.tb07362.x.

DOI:10.1111/j.1365-2141.1985.tb07362.x

Abstract

A case of Philadelphia (Ph1) chromosome negative chronic myeloid leukaemia (CML) developed lymphoid crisis. Immunological marker studies disclosed that the lymphoid cells were sheep erythrocyte-rosetting-, Leu-1+, Leu-5+, OKT-4+, OKT-8+, common ALL antigen-, HLA-DR-, cytoplasmic and surface immunoglobulin-, MAS 036C(antithymocyte)+ (after in vitro culture) and terminal deoxynucleotidyl transferase-, indicating T-cell phenotypes, probably of common thymocytes. Cytochemical staining also demonstrated immature T-cell characters: dot-positivity for acid phosphatase and beta-glucuronidase, and negative for acid alpha-naphthyl acetate esterase. All bone marrow metaphases exhibited normal karyotypes. Our observation suggests that the neoplastic features of a common stem cell for myeloid and lymphoid cell lines are very similar in Ph1 positive and negative CMLs, and that the stem cell can differentiate towards T-lineage.

摘要

1例费城（Ph1）染色体阴性的慢性粒细胞白血病（CML）发生了淋巴细胞危象。免疫标志物研究显示，淋巴细胞呈绵羊红细胞玫瑰花结形成阳性、Leu-1阳性、Leu-5阳性、OKT-4阳性、OKT-8阳性、普通急性淋巴细胞白血病抗原阴性、HLA-DR阴性、胞质和表面免疫球蛋白阴性、MAS 036C（抗胸腺细胞）阳性（体外培养后）以及末端脱氧核苷酸转移酶阴性，表明为T细胞表型，可能是普通胸腺细胞。细胞化学染色也显示出不成熟T细胞特征：酸性磷酸酶和β-葡萄糖醛酸酶呈点状阳性，酸性α-萘乙酸酯酶呈阴性。所有骨髓中期细胞均显示正常核型。我们的观察表明，在Ph1阳性和阴性的CML中，髓系和淋巴系细胞系共同干细胞的肿瘤特征非常相似，并且该干细胞可向T系分化。