表现出早期T原始细胞特征的慢性髓性白血病Ph1阳性原始细胞危象

Ph1 positive blast crisis of chronic myeloid leukaemia exhibiting features characteristic of early T blasts.

作者信息

Herrmann F, Komischke B, Kolecki P, Ludwig W D, Sieber G, Teichmann H, Rühl H

出版信息

Scand J Haematol. 1984 Apr;32(4):411-6. doi: 10.1111/j.1600-0609.1984.tb00697.x.

DOI:10.1111/j.1600-0609.1984.tb00697.x

Abstract

Leukaemic cells from a patient in the blast crisis of chronic myeloid leukaemia were subjected to a surface marker analysis using a panel of monoclonal antibodies recognizing differentiation antigens of myeloid (MY7, MY906, VIM D5, M phi P9), erythroid (VIE G4), megakaryocyte (AN51), T-lymphoid (WT1, 10.2, OKT3, OKT4, OKT6, OKT8, OKT11A) and B-lymphoid cells (B1, B2, Y29/55), common ALL-antigen (VILA1), non-lineage-restricted antigens (OKT9, OKT10), monomorphic HLA-DR determinants (7.2) as well as TdT. When the patient entered his first blast crisis, his blasts expressed a phenotype corresponding to an immature myeloid cell (7.2+, MY7+, My906+, VIM D5-). Ph1-chromosome-positive blasts from this patient's first relapse had completely changed their surface marker characteristics: they had become TdT-positive and exhibited surface features characteristic of early T blasts (WT1+, 10.2+, OKT9+, OKT10+, 7.2-, OKT6-). Together, these features provide evidence that myeloid cells may share a common precursor with T cells.

摘要

利用一组单克隆抗体，对一名处于慢性髓性白血病急变期患者的白血病细胞进行了表面标志物分析。这些单克隆抗体可识别髓系（MY7、MY906、VIM D5、M phi P9）、红系（VIE G4）、巨核细胞系（AN51）、T淋巴细胞系（WT1、10.2、OKT3、OKT4、OKT6、OKT8、OKT11A）和B淋巴细胞系（B1、B2、Y29/55）的分化抗原、普通急性淋巴细胞白血病抗原（VILA1）、非谱系限制性抗原（OKT9、OKT10）、单态性HLA - DR决定簇（7.2）以及末端脱氧核苷酸转移酶（TdT）。当该患者进入首次急变期时，其原始细胞表现出与未成熟髓系细胞相对应的表型（7.2 +、MY7 +、My906 +、VIM D5 -）。该患者首次复发时的Ph1染色体阳性原始细胞已完全改变其表面标志物特征：它们变为TdT阳性，并表现出早期T原始细胞的表面特征（WT1 +、10.2 +、OKT9 +、OKT10 +、7.2 -、OKT6 -）。这些特征共同证明，髓系细胞可能与T细胞有共同的前体。