• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Human Z alpha 1-antitrypsin accumulates intracellularly and stimulates lysosomal activity when synthesised in the Xenopus oocyte.

作者信息

Bathurst I C, Errington D M, Foreman R C, Judah J D, Carrell R W

出版信息

FEBS Lett. 1985 Apr 22;183(2):304-8. doi: 10.1016/0014-5793(85)80798-5.

DOI:10.1016/0014-5793(85)80798-5
PMID:3872810
Abstract

Microinjection of human liver mRNA from a patient homozygous for alpha 1-antitrypsin deficiency (PiZZ) into Xenopus oocytes led to a 2--10-fold increase in lysosomal activity. Stimulation of lysosomal activity was not observed when mRNA from a normal human liver (alpha 1-antitrypsin PiMM), or water was injected into the oocyte. This lysosomal activity was oocyte derived and was not due to translation products of the human liver mRNA. Thus a protein that accumulates intracellularly in the secretory pathway is capable of stimulating lysosomal activity.

摘要

相似文献

1
Human Z alpha 1-antitrypsin accumulates intracellularly and stimulates lysosomal activity when synthesised in the Xenopus oocyte.
FEBS Lett. 1985 Apr 22;183(2):304-8. doi: 10.1016/0014-5793(85)80798-5.
2
Xenopus oocytes can synthesise but do not secrete the Z variant of human alpha 1-antitrypsin.非洲爪蟾卵母细胞能够合成但不分泌人α1-抗胰蛋白酶的Z变体。
FEBS Lett. 1984 Mar 12;168(1):84-8. doi: 10.1016/0014-5793(84)80211-2.
3
Human alpha 1-antitrypsin expression in Xenopus oocytes. Secretion of the normal (PiM) and abnormal (PiZ) forms.
Eur J Biochem. 1985 Dec 2;153(2):361-5. doi: 10.1111/j.1432-1033.1985.tb09311.x.
4
Biosynthesis, processing, and secretion of M and Z variant human alpha 1-antitrypsin.M和Z变异型人α1-抗胰蛋白酶的生物合成、加工及分泌
J Biol Chem. 1986 Jul 25;261(21):9979-89.
5
The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA.α1-蛋白酶抑制剂（α1-PI）缺乏症中的细胞缺陷在人类单核细胞以及注射了人类肝脏mRNA的非洲爪蟾卵母细胞中表现出来。
Proc Natl Acad Sci U S A. 1985 Oct;82(20):6918-21. doi: 10.1073/pnas.82.20.6918.
6
Translation and processing of normal (PiMM) and abnormal (PiZZ) human alpha 1-antitrypsin.
FEBS Lett. 1983 Mar 21;153(2):270-4. doi: 10.1016/0014-5793(83)80622-x.
7
Expression of rat liver cell membrane transporters for thyroid hormone in Xenopus laevis oocytes.大鼠肝细胞甲状腺激素膜转运体在非洲爪蟾卵母细胞中的表达
Endocrinology. 1997 May;138(5):1841-6. doi: 10.1210/endo.138.5.5114.
8
Choline acetyltransferase and acetylcholine in Xenopus oocytes injected with mRNA from the electric lobe of Torpedo.注射来自电鳐电叶mRNA的非洲爪蟾卵母细胞中的胆碱乙酰转移酶和乙酰胆碱
Proc Natl Acad Sci U S A. 1985 Jan;82(2):608-11. doi: 10.1073/pnas.82.2.608.
9
Xtr, a plural tudor domain-containing protein, is involved in the translational regulation of maternal mRNA during oocyte maturation in Xenopus laevis.Xtr，一种包含多个 tudor 结构域的蛋白，参与了非洲爪蟾卵母细胞成熟过程中母源 mRNA 的翻译调控。
Dev Growth Differ. 2012 Aug;54(6):660-71. doi: 10.1111/j.1440-169X.2012.01367.x.
10
The secretion of proteins in vitro from Xenopus oocytes and their accessory cells: a biochemical and morphological study.非洲爪蟾卵母细胞及其附属细胞在体外的蛋白质分泌：一项生物化学与形态学研究。
J Embryol Exp Morphol. 1981 Feb;61:367-83.

引用本文的文献

1
Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage.导致老化卵母细胞对氧化损伤易感性增加的分子机制。
Oxid Med Cell Longev. 2017;2017:4015874. doi: 10.1155/2017/4015874. Epub 2017 Oct 18.
2
The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin.网格蛋白分拣受体 sortilin 在α-1 抗胰蛋白酶的运输中发挥作用。
Genetics. 2012 Nov;192(3):889-903. doi: 10.1534/genetics.112.143487. Epub 2012 Aug 24.
3
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.
α1-抗胰蛋白酶：分子病理学、白细胞与组织损伤
J Clin Invest. 1986 Dec;78(6):1427-31. doi: 10.1172/JCI112731.
4
Alpha 1-antitrypsin deficiency and liver disease.α1-抗胰蛋白酶缺乏症与肝脏疾病
J Inherit Metab Dis. 1991;14(4):512-25. doi: 10.1007/BF01797921.