Department of Pharmacology, Division of Glocal Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan.
Department of Otorhinolaryngology, Graduate School of Medicine, Osaka University, Osaka, Japan.
PLoS One. 2024 May 10;19(5):e0303375. doi: 10.1371/journal.pone.0303375. eCollection 2024.
Hearing loss is a pivotal risk factor for dementia. It has recently emerged that a disruption in the intercommunication between the cochlea and brain is a key process in the initiation and progression of this disease. However, whether the cochlear properties can be influenced by pathological signals associated with dementia remains unclear. In this study, using a mouse model of Alzheimer's disease (AD), we investigated the impacts of the AD-like amyloid β (Aβ) pathology in the brain on the cochlea. Despite little detectable change in the age-related shift of the hearing threshold, we observed quantitative and qualitative alterations in the protein profile in perilymph, an extracellular fluid that fills the path of sound waves in the cochlea. Our findings highlight the potential contribution of Aβ pathology in the brain to the disturbance of cochlear homeostasis.
听力损失是痴呆的一个关键风险因素。最近有研究表明，耳蜗和大脑之间的相互通讯中断是这种疾病发生和发展的关键过程。然而，耳蜗的特性是否会受到与痴呆相关的病理信号的影响尚不清楚。在这项研究中，我们使用阿尔茨海默病（AD）的小鼠模型，研究了大脑中类似 AD 的淀粉样 β（Aβ）病理学对耳蜗的影响。尽管在与年龄相关的听力阈值变化中几乎没有检测到变化，但我们观察到外淋巴（耳蜗中充满声波路径的细胞外液）中的蛋白质谱发生了定量和定性的改变。我们的研究结果强调了大脑中的 Aβ 病理学对耳蜗内稳态紊乱的潜在贡献。
