Emergency Department, Cangzhou Central Hospital, Yunhe Qu, Cangzhou, China.
Medicine (Baltimore). 2024 May 10;103(19):e38035. doi: 10.1097/MD.0000000000038035.
The objective of this meta-analysis is to evaluate the diagnostic performance of acoustic radiation force impulse (ARFI) in acute pancreatitis (AP) patients.
PubMed, Web of Science, Embase, Wanfang, Chinese Biological Medicine databases, and Chinese Biomedical Literature Service System were searched for relevant studies to explore the potential diagnostic performance of ARFI in AP from inception to November 2023. STATA 14.0 was used to analyze the standardized mean difference (SMD) with 95% confidence interval (CI), pooled sensitivity, specificity, area under the curve, meta-regression analysis, sensitivity analysis, and publication bias.
Nine studies, involving 533 AP patients and 585 healthy controls, were included. AP patients had significantly higher ARFI levels than healthy controls (SMD: 3.13, 95% CI: 1.88-4.39, P = .001). The area under the curve of ARFI for diagnosing AP was 0.99 (95% CI: 0.98-1.00), with 98% sensitivity and 94% specificity. Meta-regression identified the study region and study period as the sources of heterogeneity. Sensitivity analysis showed that the exclusion of any single study did not materially alter the overall combined effect. No evidence of publication bias was observed in the included studies.
This meta-analysis demonstrated that ARFI exerted satisfactory diagnostic performance in AP.
本荟萃分析旨在评估声辐射力脉冲（ARFI）在急性胰腺炎（AP）患者中的诊断性能。
检索PubMed、Web of Science、Embase、万方、中国生物医学文献服务系统和中国生物医学文献数据库，以探讨 ARFI 在 AP 中的潜在诊断性能，时间从建库至 2023 年 11 月。采用 STATA 14.0 软件进行分析，使用标准化均数差（SMD）和 95%置信区间（CI）进行合并，计算敏感性、特异性、曲线下面积、Meta 回归分析、敏感性分析和发表偏倚。
纳入了 9 项研究，共 533 例 AP 患者和 585 例健康对照者。AP 患者的 ARFI 水平明显高于健康对照组（SMD：3.13，95%CI：1.88-4.39，P =.001）。ARFI 诊断 AP 的曲线下面积为 0.99（95%CI：0.98-1.00），具有 98%的敏感性和 94%的特异性。Meta 回归分析确定研究区域和研究时期是异质性的来源。敏感性分析显示，排除任何单个研究都不会明显改变整体合并效应。纳入的研究中未发现发表偏倚的证据。
本荟萃分析表明，ARFI 在 AP 中具有较好的诊断性能。
