Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City 90000, Vietnam.
Laboratory of Nam Khoa Biotek Company, Vietnam Research and Development Institute of Clinical Microbiology, Ho Chi Minh City 700000, Vietnam.
J Infect Dev Ctries. 2024 Apr 30;18(4):495-500. doi: 10.3855/jidc.18900.
After the Coronavirus Disease 2019 pandemic, a high number of cases and severe dengue in children were reported in some provinces in the south of Vietnam. This study aimed to determine the distribution of dengue virus serotypes and their correlation with demographic factors, disease severity, clinical manifestations, and laboratory findings.
This study employed a cross-sectional design. Ninety-six dengue-infected children admitted to Can Tho Children's Hospital between October 2022 and March 2023 were included. Confirmation of dengue infection was achieved through the real-time polymerase chain reaction (RT-PCR).
Among the identified serotypes, DENV-2 accounted for the highest proportion (71.87%), followed by DENV-1 (23.96%), and DENV-4 (4.17%). DENV-3 was not detected. No significant demographic, disease severity, or laboratory differences were observed among the identified dengue serotypes. However, DENV-2 was associated with a higher occurrence of mucous membrane hemorrhages and gastrointestinal bleeding compared to other serotypes.
Although DENV-2 was the most prevalent serotype responsible for dengue in children in southern Vietnam, it did not lead to more severe cases compared to other serotypes. This finding is crucial for evaluating the illness's prognosis.
2019 年冠状病毒病疫情过后，越南南部一些省份报告了大量儿童病例和严重登革热病例。本研究旨在确定登革热病毒血清型的分布及其与人口统计学因素、疾病严重程度、临床表现和实验室结果的相关性。
本研究采用了横断面设计。2022 年 10 月至 2023 年 3 月期间，共有 96 名登革热感染儿童入住芹苴儿童医院，将其纳入研究。通过实时聚合酶链反应（RT-PCR）确认登革热感染。
在所鉴定的血清型中，DENV-2 所占比例最高（71.87%），其次是 DENV-1（23.96%）和 DENV-4（4.17%）。未检测到 DENV-3。在所鉴定的登革热血清型中，未观察到人口统计学、疾病严重程度或实验室方面的显著差异。然而，与其他血清型相比，DENV-2 与更频繁出现粘膜出血和胃肠道出血相关。
尽管 DENV-2 是越南南部导致儿童登革热的最常见血清型，但与其他血清型相比，它并未导致更严重的病例。这一发现对于评估疾病的预后至关重要。
