Van Hale H M, Winkelmann R K
J Am Acad Dermatol. 1985 Mar;12(3):455-61. doi: 10.1016/s0190-9622(85)70063-1.
Skin biopsy specimens from six patients with nodular lymphoid disease of the head and neck were studied by routine histology, direct immunofluorescence microscopy, and leukocyte monoclonal antibodies to T and B cell subsets and monocytes. Initially, these lesions were clinically considered to be benign lymphocytic infiltrates of Jessner, lymphocytoma, or lymphoma. Direct immunofluorescence was negative or showed nonspecific staining in all four patients in whom it was performed. Leukocyte monoclonal antibody stains revealed two distinct patterns of lymphocytes. Lymphocytoma was represented by nodular masses of B lymphocytes with peripheral and intervening zones of T cells. The second pattern consisted of solid nodular masses of T lymphocytes occupying the dermis and subcutaneous tissue. In the specimens interpreted as benign lymphocytic infiltration, the T cells were composed equally of helper and suppressor cells.
对6例头颈部结节性淋巴疾病患者的皮肤活检标本进行了常规组织学、直接免疫荧光显微镜检查，并用针对T和B细胞亚群及单核细胞的白细胞单克隆抗体进行检测。最初，这些病变在临床上被认为是杰斯纳良性淋巴细胞浸润、淋巴细胞瘤或淋巴瘤。在进行直接免疫荧光检测的所有4例患者中，结果均为阴性或显示非特异性染色。白细胞单克隆抗体染色揭示了两种不同的淋巴细胞模式。淋巴细胞瘤表现为B淋巴细胞的结节状肿块，周围和中间有T细胞区。第二种模式由占据真皮和皮下组织的T淋巴细胞实性结节状肿块组成。在被解释为良性淋巴细胞浸润的标本中，T细胞由辅助细胞和抑制细胞均等组成。
