Center of Stem Cell and Regenerative Medicine, Gaozhou People's Hospital, Gaozhou 525200, China.
Center of Stem Cell and Regenerative Medicine, Gaozhou People's Hospital, Gaozhou 525200, China.
Colloids Surf B Biointerfaces. 2024 Jul;239:113942. doi: 10.1016/j.colsurfb.2024.113942. Epub 2024 May 6.
Myocardial infarction (MI) stands out as a highly lethal disease that poses a significant threat to global health. Worldwide, heart failure resulting from MI remains a leading cause of human mortality. Mesenchymal stem cell (MSC) therapy has emerged as a promising therapeutic approach, leveraging its intrinsic healing properties. Nevertheless, pervasive issues, including a low cell retention rate, suboptimal survival rate, and incomplete differentiation of MSCs, present formidable challenges for further research. The introduction and advancement of biomaterials have offered a novel avenue for the exploration of MSC therapy in MI, marking considerable progress thus far. Notably, hydrogels, among the representative biomaterials, have garnered extensive attention within the biomedical field. This review delves into recent advancements, specifically focusing on the application of hydrogels to augment MSC therapy for cardiac tissue regeneration in MI.
心肌梗死（MI）是一种高致死性疾病，对全球健康构成重大威胁。在全球范围内，MI 导致的心力衰竭仍然是人类死亡的主要原因。间充质干细胞（MSC）治疗作为一种有前途的治疗方法，利用其内在的愈合特性脱颖而出。然而，普遍存在的问题，包括低细胞保留率、MSC 存活率低和不完全分化，给进一步的研究带来了巨大的挑战。生物材料的引入和发展为 MI 中的 MSC 治疗提供了新的探索途径，迄今为止已经取得了相当大的进展。值得注意的是，水凝胶作为代表性的生物材料之一，在生物医学领域引起了广泛关注。本综述深入探讨了最近的进展，特别是聚焦于水凝胶在增强 MSC 治疗 MI 中心肌组织再生中的应用。
