Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, OH, USA.
Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, OH, USA.
Clin Neurophysiol. 2024 Jul;163:102-111. doi: 10.1016/j.clinph.2024.04.017. Epub 2024 Apr 30.
We investigated the role of transverse temporal gyrus and adjacent cortex (TTG+) in facial expressions and perioral movements.
In 31 patients undergoing stereo-electroencephalography monitoring, we describe behavioral responses elicited by electrical stimulation within the TTG+. Task-induced high-gamma modulation (HGM), auditory evoked responses, and resting-state connectivity were used to investigate the cortical sites having different types of responses on electrical stimulation.
Changes in facial expressions and perioral movements were elicited on electrical stimulation within TTG+ in 9 (29%) and 10 (32%) patients, respectively, in addition to the more common language responses (naming interruptions, auditory hallucinations, paraphasic errors). All functional sites showed auditory task induced HGM and evoked responses validating their location within the auditory cortex, however, motor sites showed lower peak amplitudes and longer peak latencies compared to language sites. Significant first-degree connections for motor sites included precentral, anterior cingulate, parahippocampal, and anterior insular gyri, whereas those for language sites included posterior superior temporal, posterior middle temporal, inferior frontal, supramarginal, and angular gyri.
Multimodal data suggests that TTG+ may participate in auditory-motor integration.
TTG+ likely participates in facial expressions in response to emotional cues during an auditory discourse.
我们研究了横颞回及毗邻皮质（TTG+）在面部表情和口周运动中的作用。
在 31 例行立体脑电图监测的患者中，我们描述了 TTG+内电刺激引起的行为反应。利用任务诱导的高频γ调制（HGM）、听觉诱发电位和静息状态连接来研究具有不同电刺激反应类型的皮质部位。
在 TTG+内电刺激可引起 9 例（29%）和 10 例（32%）患者的面部表情和口周运动变化，此外还有更常见的语言反应（命名中断、听觉幻觉、错语）。所有功能部位均显示听觉任务诱导的 HGM 和诱发电位，证实其位于听觉皮层内，但运动部位的峰值幅度较低，峰值潜伏期较长，与语言部位相比。运动部位的显著一级连接包括中央前回、扣带回前回、海马旁回和前脑岛，而语言部位的一级连接包括后上颞回、后中颞回、下额回、缘上回和角回。
多模态数据表明 TTG+可能参与听觉-运动整合。
TTG+可能参与对听觉话语中情感线索的面部表情反应。
