Department of Food Science and Engineering, Ningbo University, Ningbo 315211, PR China.
College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
Food Res Int. 2024 Jun;186:114404. doi: 10.1016/j.foodres.2024.114404. Epub 2024 Apr 21.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an unknown etiology. It is associated with various factors and causes great inconvenience to the patient's life. The gut-brain axis (GBA), which serves as a bidirectional information channel for exchanging information between the gut microbiota and the brain, is vital in studying many neurodegenerative diseases. Dietary flavonoids provide anti-inflammatory and antioxidant benefits, as well as regulating the structure and function of the gut microbiota. The occurrence and development of ASD are associated with dysbiosis of the gut microbiota. Modulation of gut microbiota can effectively improve the severity of ASD. This paper reviews the links between gut microbiota, flavonoids, and ASD, focusing on the mechanism of dietary flavonoids in regulating ASD through the GBA.
自闭症谱系障碍（ASD）是一种神经发育障碍，其病因不明。它与各种因素有关，给患者的生活带来极大不便。肠道-大脑轴（GBA）作为肠道微生物群和大脑之间信息交流的双向信息通道，在研究许多神经退行性疾病中至关重要。饮食类黄酮提供抗炎和抗氧化作用，并调节肠道微生物群的结构和功能。ASD 的发生和发展与肠道微生物群的失调有关。调节肠道微生物群可以有效改善 ASD 的严重程度。本文综述了肠道微生物群、类黄酮与 ASD 之间的联系，重点探讨了饮食类黄酮通过 GBA 调节 ASD 的机制。
