Ferreira Izabela, da Costa Diego Morita Gomes, Dos Reis Andrea Cândido
Undergraduate student, Department of Dental Materials and Prosthodontics, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto, Brazil.
Graduate student, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto, Brazil.
J Prosthet Dent. 2024 May 9. doi: 10.1016/j.prosdent.2024.04.011.
Incorporating and coating with antimicrobials are techniques that can confer antimicrobial action on polymethyl methacrylate (PMMA) denture bases, which can accumulate microorganisms and promote oral and systemic disease.
The purpose of this systematic review was to answer the question: "Do techniques for incorporating and coating antimicrobial agents in PMMA promote antimicrobial action?"
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist guidelines were followed, and the SCOPUS, PubMed/Medline, EMBASE, and Science Direct databases searched. The studies were selected in 2 stages, reading the titles and abstracts and then reading the selected studies in full. The risk of bias was analyzed by adapting the quasi-experimental studies tool by the Joanna Briggs Institute (JBI).
A total of 970 articles were found in the databases; 71 were duplicates and, after reading the abstracts, 38 were selected for full reading. From these, 6 were excluded because they did not fulfill the inclusion criteria, and 32 studies were included in this review. Autopolymerizing, heat- polymerizing, and light-polymerizing resins were evaluated, with the incorporating technique prevailing over the coating, but both techniques effectively promoted antimicrobial activity.
Incorporating and coating antimicrobial agents are effective methods of promoting antimicrobial activity in PMMA. Combining the 2 methods led to increased antimicrobial activity compared with each individually.
添加抗菌剂并进行涂层处理是能够赋予聚甲基丙烯酸甲酯（PMMA）义齿基托抗菌作用的技术，义齿基托会积聚微生物并引发口腔和全身疾病。
本系统评价的目的是回答以下问题：“在PMMA中添加和涂层抗菌剂的技术是否能促进抗菌作用？”
遵循系统评价和Meta分析的首选报告项目（PRISMA）清单指南，并检索了SCOPUS、PubMed/Medline、EMBASE和Science Direct数据库。研究分两个阶段进行筛选，先阅读标题和摘要，然后阅读选定研究的全文。采用乔安娜·布里格斯研究所（JBI）的准实验研究工具分析偏倚风险。
在数据库中总共找到970篇文章；其中71篇为重复文章，阅读摘要后，选定38篇进行全文阅读。其中6篇因不符合纳入标准而被排除，本评价纳入32项研究。对自凝、热凝和光固化树脂进行了评估，添加技术比涂层技术更常用，但两种技术均有效促进了抗菌活性。
添加和涂层抗菌剂是促进PMMA抗菌活性的有效方法。与单独使用每种方法相比，将两种方法结合可提高抗菌活性。
