Marinho Vanessa Teixeira, Dos Reis Andréa Cândido, da Costa Valente Mariana Lima
Department of Dental Materials and Prosthodontics, Ribeirão Preto Dental School, University of São Paulo (USP), Ribeirão Preto 14040-904, Brazil.
Antibiotics (Basel). 2022 Oct 14;11(10):1413. doi: 10.3390/antibiotics11101413.
The aim of this systematic review was to verify if the presence of different antimicrobial agents in dentifrices is effective in reducing the number of microorganisms for disease prevention. This review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines and was registered with the Open Science Framework (OSF). A search was conducted in the PubMed, Embase, Scopus, and Web of Science databases. Two independent authors reviewed the titles and abstracts according to the inclusion criteria, which comprised in vitro studies published in English that evaluated the efficacy of antimicrobial agents in dentifrices and their antimicrobial activity. A total of 527 articles were found. Of these, 334 were included for reading of the title and abstract, and 69 were selected for reading in full. In the end, 39 articles remained in this review. Triclosan, sodium fluoride, and sodium monofluorophosphate were the most commonly used chemical antimicrobial agents. Among the herbal agents, miswak extract and neem extract were the most commonly used. The presence of antimicrobial agents in dentifrice formulations can promote the reduction of the number of microorganisms involved in oral diseases, but with variations in their effectiveness, depending on the agent used and the microorganism evaluated.
本系统评价的目的是验证牙膏中不同抗菌剂的存在是否能有效减少微生物数量以预防疾病。本评价遵循系统评价和Meta分析的首选报告项目（PRISMA）指南，并在开放科学框架（OSF）上进行了注册。在PubMed、Embase、Scopus和Web of Science数据库中进行了检索。两名独立作者根据纳入标准对标题和摘要进行了审查，纳入标准包括以英文发表的体外研究，这些研究评估了牙膏中抗菌剂的功效及其抗菌活性。共找到527篇文章。其中，334篇被纳入标题和摘要阅读，69篇被选入全文阅读。最终，本评价保留了39篇文章。三氯生、氟化钠和单氟磷酸钠是最常用的化学抗菌剂。在草药制剂中，阿拉伯树牙刷提取物和印楝提取物是最常用的。牙膏配方中抗菌剂的存在可以促进减少口腔疾病相关微生物的数量，但效果存在差异，这取决于所使用的抗菌剂和所评估的微生物。
