Becker C M, Gueuning C O, Graff G L
Microsurgery. 1985;6(1):1-10. doi: 10.1002/micr.1920060102.
Peripheral nerve anastomoses using either epiperineurial sutures or a fibrinogen adhesive technique have been compared in the rat sciatic nerve model. Evaluation of results was made using radiolabelling of the metabolically active acid-soluble phosphate fractions of both nerve and muscle. In none of the situations tested--traumatic degeneration and regeneration in the sciatic nerve proximal segment, Wallerian degeneration and regeneration in its distal segment, atrophy and regeneration of the fast gastrocnemius muscle, and atrophy and regeneration of the slow soleus muscle--was one repair method significantly superior to the other. A significant degree of cross-reinnervation was shown to take place after anastomosis, altering the characteristics of the regenerating muscles. Both repair methods were equally inferior to the spontaneous repair occurring after a simple nerve crush.
在大鼠坐骨神经模型中，对使用神经外膜缝合或纤维蛋白原黏合技术进行的周围神经吻合术进行了比较。使用神经和肌肉代谢活性酸溶性磷酸盐部分的放射性标记对结果进行评估。在测试的任何情况下——坐骨神经近端段的创伤性变性和再生、其远端段的华勒氏变性和再生、快肌腓肠肌的萎缩和再生以及慢肌比目鱼肌的萎缩和再生——一种修复方法均未显著优于另一种。吻合术后显示发生了显著程度的交叉神经支配，改变了再生肌肉的特征。两种修复方法均同样逊于单纯神经挤压后发生的自发修复。
