Cruz N I, Debs N, Fiol R E
Plast Reconstr Surg. 1986 Sep;78(3):369-73. doi: 10.1097/00006534-198609000-00015.
Using the rat sciatic nerve model, we evaluated the merits of homologous fibrin glue in the repair of peripheral nerve transections as compared to standard epineural suture repairs. A total of four study groups were used, with 10 animals assigned to each group. In group I, the transected sciatic nerve was repaired with six interrupted 10-0 nylon sutures; in group II, only two interrupted sutures were used; in group III, a two-suture repair was reinforced with fibrin glue; and in group IV, only fibrin glue was used. All animals were sacrificed at 8 weeks, and histologic sections evaluated. When fibrin alone was used, dehiscence occurred in 80 percent of the animals, and as reinforcement of a two-suture repair, it only increased the inflammatory reaction.
利用大鼠坐骨神经模型，我们评估了与标准神经外膜缝合修复相比，同种异体纤维蛋白胶在修复周围神经横断伤方面的优点。总共使用了四个研究组，每组分配10只动物。在第一组中，用6根间断的10-0尼龙缝线修复横断的坐骨神经；在第二组中，仅使用两根间断缝线；在第三组中，用纤维蛋白胶加强两针缝合修复；在第四组中，仅使用纤维蛋白胶。所有动物在8周时处死，并对组织切片进行评估。当单独使用纤维蛋白胶时，80%的动物出现裂开，而作为两针缝合修复的加强手段，它只会增加炎症反应。
