Daniele Alberto, Rosso Roberta, Ceccaroni Marcello, Roviglione Giovanni, D'Ancona Gianmarco, Peano Elisa, Clignon Valentino, Calandra Valerio, Puppo Andrea
Department of Gynecology and Obstetrics, Azienda Sanitaria Ospedaliera Santa Croce e Carle, 12100 Cuneo, Italy.
Department of Obstetrics and Gynecology, IRCCS "Sacro Cuore-Don Calabria" Hospital, 37024 Negrar di Valpolicella, Italy.
Cancers (Basel). 2024 Apr 24;16(9):1631. doi: 10.3390/cancers16091631.
(1) Background: Minimally invasive surgery (MIS) represents a feasible approach in early-stage ovarian cancer, while this question is still unsolved for advanced and recurrent disease. (2) Methods: In this retrospective, multicenter study, we present a series of 21 patients who underwent MIS for primitive or recurrent epithelial ovarian cancer (EOC) with bulky nodal metastasis and discuss surgical technique and outcomes in relation to the current literature. (3) Results: Complete cytoreduction at primary debulking surgery was obtained in 86% of cases. No complication occurred in our patients intraoperatively and only 11.1% of our patients experienced grade 2 and 3 postoperative complications. Notably, all the patients with isolated lymph nodal recurrence (ILNR) were successfully treated with a minimally invasive approach with no intra- or postoperative complications. (4) Conclusions: The results of our study are consistent with those reported in the literature, demonstrating that MIS may represent a safe approach in advanced and recurrent EOC with nodal metastasis if performed on selected patients by expert surgeons with an adequate setting and appropriate technique.
（1）背景：微创手术（MIS）是早期卵巢癌的一种可行治疗方法，但对于晚期和复发性疾病，这个问题仍未得到解决。（2）方法：在这项回顾性多中心研究中，我们报告了一系列21例接受MIS治疗原发性或复发性上皮性卵巢癌（EOC）且伴有巨大淋巴结转移的患者，并结合当前文献讨论了手术技术和结果。（3）结果：86%的病例在初次肿瘤细胞减灭术中实现了完全细胞减灭。我们的患者术中未发生并发症，仅11.1%的患者术后出现2级和3级并发症。值得注意的是，所有孤立性淋巴结复发（ILNR）患者均通过微创方法成功治疗，术中及术后均无并发症。（4）结论：我们的研究结果与文献报道一致，表明如果由经验丰富的外科医生在适当的环境下采用合适的技术对选定患者进行手术，MIS可能是晚期和复发性伴有淋巴结转移的EOC的一种安全治疗方法。
