• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

ATP1A1的低甲基化与三阴性乳腺癌的不良预后和癌症进展相关。

Hypomethylation of ATP1A1 Is Associated with Poor Prognosis and Cancer Progression in Triple-Negative Breast Cancer.

作者信息

Kim Yesol, Ko Je Yeong, Kong Hyun Kyung, Lee Minyoung, Chung Woosung, Lim Sera, Son Dasom, Oh Sumin, Park Jee Won, Kim Do Yeon, Lee Minju, Han Wonshik, Park Woong-Yang, Yoo Kyung Hyun, Park Jong Hoon

机构信息

Department of Biological Science, Research Institute of Women's Health, Sookmyung Women's University, Seoul 04310, Republic of Korea.

Samsung Genome Institute, Samsung Medical Center, Seoul 06351, Republic of Korea.

出版信息

Cancers (Basel). 2024 Apr 25;16(9):1666. doi: 10.3390/cancers16091666.

DOI:10.3390/cancers16091666
PMID:38730618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11083557/
Abstract

Dysregulated DNA methylation in cancer is critical in the transcription machinery associated with cancer progression. Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, but no treatment targeting TNBC biomarkers has yet been developed. To identify specific DNA methylation patterns in TNBC, methyl-binding domain protein 2 (MBD) sequencing data were compared in TNBC and the three other major breast cancer subtypes. Integrated analysis of DNA methylation and gene expression identified a gene set showing a correlation between DNA methylation and gene expression. ATPase Na+/K+-transporting subunit alpha 1 (ATP1A1) was found to be specifically hypomethylated in the coding sequence (CDS) region and to show increased expression in TNBC. The Cancer Genome Atlas (TCGA) database also showed that hypomethylation and high expression of ATP1A1 were strongly associated with poor survival in patients with TNBC. Furthermore, ATP1A1 knockdown significantly reduced the viability and tumor-sphere formation of TNBC cells. These results suggest that the hypomethylation and overexpression of ATP1A1 could be a prognostic marker in TNBC and that the manipulation of ATP1A1 expression could be a therapeutic target in this disease.

摘要

癌症中失调的DNA甲基化在与癌症进展相关的转录机制中至关重要。三阴性乳腺癌（TNBC）是最具侵袭性的乳腺癌亚型，但尚未开发出针对TNBC生物标志物的治疗方法。为了确定TNBC中的特定DNA甲基化模式，对TNBC和其他三种主要乳腺癌亚型的甲基结合域蛋白2（MBD）测序数据进行了比较。DNA甲基化和基因表达的综合分析确定了一组显示DNA甲基化与基因表达之间相关性的基因。发现ATP酶Na+/K+转运亚基α1（ATP1A1）在编码序列（CDS）区域中特异性低甲基化，并在TNBC中表达增加。癌症基因组图谱（TCGA）数据库还显示，ATP1A1的低甲基化和高表达与TNBC患者的不良生存密切相关。此外，ATP1A1敲低显著降低了TNBC细胞的活力和肿瘤球形成。这些结果表明，ATP1A1的低甲基化和过表达可能是TNBC的预后标志物，并且操纵ATP1A1的表达可能是这种疾病的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/05eb759deefe/cancers-16-01666-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/948bde500db3/cancers-16-01666-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/c0f2c78ae2d9/cancers-16-01666-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/52bb61b79674/cancers-16-01666-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/9d7158bae6cf/cancers-16-01666-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/c0bf5b50fdb8/cancers-16-01666-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/05eb759deefe/cancers-16-01666-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/948bde500db3/cancers-16-01666-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/c0f2c78ae2d9/cancers-16-01666-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/52bb61b79674/cancers-16-01666-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/9d7158bae6cf/cancers-16-01666-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/c0bf5b50fdb8/cancers-16-01666-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0622/11083557/05eb759deefe/cancers-16-01666-g006.jpg

相似文献

1
Hypomethylation of ATP1A1 Is Associated with Poor Prognosis and Cancer Progression in Triple-Negative Breast Cancer.ATP1A1的低甲基化与三阴性乳腺癌的不良预后和癌症进展相关。
Cancers (Basel). 2024 Apr 25;16(9):1666. doi: 10.3390/cancers16091666.
2
Epigenomic Profiling Advises Therapeutic Potential of Leukotriene Receptor Inhibitors for a Subset of Triple-Negative Breast Tumors.表观基因组分析提示白三烯受体抑制剂对部分三阴性乳腺癌的治疗潜力。
Int J Mol Sci. 2023 Dec 11;24(24):17343. doi: 10.3390/ijms242417343.
3
Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer.较高水平的基质金属蛋白酶组织抑制因子-1（TIMP-1）表达与三阴性乳腺癌的不良预后相关。
Mol Cancer. 2016 Apr 30;15(1):30. doi: 10.1186/s12943-016-0515-5.
4
Epigenetic hypomethylation and upregulation of GD3s in triple negative breast cancer.三阴性乳腺癌中GD3s的表观遗传低甲基化及上调
Ann Transl Med. 2019 Dec;7(23):723. doi: 10.21037/atm.2019.12.23.
5
High expression of TLR3 in triple-negative breast cancer predicts better prognosis-data from the Fudan University Shanghai Cancer Center cohort and tissue microarrays.TLR3 在三阴性乳腺癌中的高表达预示着更好的预后——来自复旦大学上海癌症中心队列和组织微阵列的数据。
BMC Cancer. 2023 Apr 1;23(1):298. doi: 10.1186/s12885-023-10721-9.
6
SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer.SPAG5 上调通过与三阴性乳腺癌中 c-MYC 结合蛋白相互作用促进 c-MYC 转录活性。
J Hematol Oncol. 2019 Feb 8;12(1):14. doi: 10.1186/s13045-019-0700-2.
7
Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer.多组学分析显示 CT83 是三阴性乳腺癌最特异的基因，其低甲基化在乳腺癌中具有致癌性。
Sci Rep. 2021 Jun 9;11(1):12172. doi: 10.1038/s41598-021-91290-4.
8
Identification of DDIT4 as a potential prognostic marker associated with chemotherapeutic and immunotherapeutic response in triple-negative breast cancer.鉴定 DDIT4 作为三阴性乳腺癌化疗和免疫治疗反应相关的潜在预后标志物。
World J Surg Oncol. 2023 Jun 30;21(1):194. doi: 10.1186/s12957-023-03078-7.
9
Long non-coding RNA HUMT hypomethylation promotes lymphangiogenesis and metastasis via activating FOXK1 transcription in triple-negative breast cancer.长非编码 RNA HUMT 低甲基化通过激活三阴性乳腺癌中的 FOXK1 转录促进淋巴管生成和转移。
J Hematol Oncol. 2020 Mar 5;13(1):17. doi: 10.1186/s13045-020-00852-y.
10
Regulator of G protein signaling 20 correlates with clinicopathological features and prognosis in triple-negative breast cancer.G蛋白信号调节因子20与三阴性乳腺癌的临床病理特征及预后相关。
Biochem Biophys Res Commun. 2017 Apr 8;485(3):693-697. doi: 10.1016/j.bbrc.2017.02.106. Epub 2017 Feb 22.

引用本文的文献

1
Targeting Sodium Transport Reveals CHP1 Downregulation as a Novel Molecular Feature of Malignant Progression in Clear Cell Renal Cell Carcinoma: Insights from Integrated Multi-Omics Analyses.靶向钠转运揭示CHP1下调是透明细胞肾细胞癌恶性进展的一种新分子特征：来自综合多组学分析的见解
Biomolecules. 2025 Jul 15;15(7):1019. doi: 10.3390/biom15071019.

本文引用的文献

1
The expression of the alpha1 subunit of Na/K-ATPase is related to tumor development and clinical outcomes in gastric cancer.钠钾ATP酶α1亚基的表达与胃癌的肿瘤发展及临床结局相关。
Gastric Cancer. 2021 Nov;24(6):1278-1292. doi: 10.1007/s10120-021-01212-6. Epub 2021 Jul 12.
2
Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency.三阴性乳腺癌基因组改变与同源重组缺陷的综合分析
PLoS Genet. 2017 Jun 21;13(6):e1006853. doi: 10.1371/journal.pgen.1006853. eCollection 2017 Jun.
3
Abnormal expression of and in breast cancer.
乳腺癌中[具体基因名称未给出]和[具体基因名称未给出]的异常表达。
F1000Res. 2017 Jan 5;6:10. doi: 10.12688/f1000research.10481.1. eCollection 2017.
4
Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma.离子转运蛋白和 MAP 激酶通路抑制剂在黑色素瘤中的协同作用。
Nat Commun. 2016 Aug 22;7:12336. doi: 10.1038/ncomms12336.
5
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.心脏糖苷对 STK11 突变型肺癌显示出选择性疗效。
Sci Rep. 2016 Jul 19;6:29721. doi: 10.1038/srep29721.
6
Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma.钠钾ATP酶α1亚基，一种新型的肝细胞癌治疗靶点。
Oncotarget. 2015 Sep 29;6(29):28183-93. doi: 10.18632/oncotarget.4726.
7
Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis.转录网络的协同表观遗传重塑发生在早期乳腺癌发生过程中。
Clin Epigenetics. 2015 May 1;7(1):52. doi: 10.1186/s13148-015-0086-0. eCollection 2015.
8
Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.三阴性乳腺癌中的甲基化组测序揭示了具有预后价值的不同甲基化簇。
Nat Commun. 2015 Feb 2;6:5899. doi: 10.1038/ncomms6899.
9
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells.缺氧诱导因子是乳腺癌干细胞化疗耐药所必需的。
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5429-38. doi: 10.1073/pnas.1421438111. Epub 2014 Dec 1.
10
Cardiac glycoside activities link Na(+)/K(+) ATPase ion-transport to breast cancer cell migration via correlative SAR.强心苷活性通过相关构效关系将Na(+)/K(+) ATP酶离子转运与乳腺癌细胞迁移联系起来。
ACS Chem Biol. 2015 Feb 20;10(2):561-9. doi: 10.1021/cb500665r. Epub 2014 Nov 26.