编码来自大鼠-小鼠T细胞杂交瘤的IgE结合因子的cDNA克隆。
cDNA clones encoding IgE-binding factors from a rat-mouse T-cell hybridoma.
作者信息
Martens C L, Huff T F, Jardieu P, Trounstine M L, Coffman R L, Ishizaka K, Moore K W
出版信息
Proc Natl Acad Sci U S A. 1985 Apr;82(8):2460-4. doi: 10.1073/pnas.82.8.2460.
Abstract
cDNA clones encoding rodent IgE-binding factors (IgE-BF) were isolated from cDNA libraries of a rat-mouse T hybridoma that secretes IgE-suppressive factor (IgE-SF) upon incubation with rat IgE. COS7 cells transfected with two of the cDNAs expressed IgE-BF, which selectively potentiate an in vitro IgE response. IgE-BF expressed in COS7 cells are glycoproteins of approximately equal to 60 and approximately equal to 11 kDa. DNA sequence analysis of an IgE-BF cDNA revealed a 556-amino acid (62 kDa) protein coding region. The results suggest that IgE-potentiating and IgE-suppressive factors share common precursor polypeptides and that the 11-kDa IgE-BF is derived from a 60-kDa precursor.
摘要
从大鼠 - 小鼠T杂交瘤的cDNA文库中分离出编码啮齿动物IgE结合因子（IgE - BF）的cDNA克隆，该杂交瘤在与大鼠IgE孵育时分泌IgE抑制因子（IgE - SF）。用其中两个cDNA转染的COS7细胞表达IgE - BF，其选择性增强体外IgE反应。在COS7细胞中表达的IgE - BF是约60 kDa和约11 kDa的糖蛋白。对IgE - BF cDNA的DNA序列分析揭示了一个556个氨基酸（62 kDa）的蛋白质编码区。结果表明，IgE增强因子和IgE抑制因子共享共同的前体多肽，并且11 kDa的IgE - BF源自60 kDa的前体。
相似文献
1
cDNA clones encoding IgE-binding factors from a rat-mouse T-cell hybridoma.编码来自大鼠-小鼠T细胞杂交瘤的IgE结合因子的cDNA克隆。
Proc Natl Acad Sci U S A. 1985 Apr;82(8):2460-4. doi: 10.1073/pnas.82.8.2460.
2
IgE-binding factors. Selective regulation of the IgE response by T cell factors.IgE结合因子。T细胞因子对IgE反应的选择性调节。
Int Arch Allergy Appl Immunol. 1985;77(1-2):13-20.
3
Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor.编码糖基化抑制因子的cDNA的分子克隆与功能表达
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10056-60. doi: 10.1073/pnas.90.21.10056.
4
cDNA clones encoding murine IgE-binding factors represent multiple structural variants of intracisternal A-particle genes.编码小鼠IgE结合因子的cDNA克隆代表了脑内A颗粒基因的多种结构变体。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6583-7. doi: 10.1073/pnas.83.17.6583.
5
6
7
Potentiating and suppressive IgE-binding factors are expressed by a single cloned gene.增强性和抑制性IgE结合因子由单一克隆基因表达。
Proc Natl Acad Sci U S A. 1987 Feb;84(3):809-13. doi: 10.1073/pnas.84.3.809.
8
9
IgE-binding factors and regulation of the IgE antibody response.IgE结合因子与IgE抗体反应的调节
Annu Rev Immunol. 1988;6:513-34. doi: 10.1146/annurev.iy.06.040188.002501.
10
Regulatory effects of human IgE-binding factors in the IgE synthesis by human and rat lymphocytes.人IgE结合因子对人和大鼠淋巴细胞合成IgE的调节作用。
Eur J Immunol. 1988 Nov;18(11):1663-70. doi: 10.1002/eji.1830181103.
引用本文的文献
1
Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase.一种源自磷酸肌醇3激酶调节亚基的新致癌基因的鉴定与表征
EMBO J. 1998 Feb 2;17(3):743-53. doi: 10.1093/emboj/17.3.743.
2
Selective expression of intracisternal A-particle genes in established mouse plasmacytomas.小鼠浆细胞瘤中核内A粒子基因的选择性表达
Mol Cell Biol. 1993 Dec;13(12):7439-46. doi: 10.1128/mcb.13.12.7439-7446.1993.
3
4
Potentiation of human immunoglobulin E synthesis by plasma immunoglobulin E binding factors from patients with the hyperimmunoglobulin E syndrome.高免疫球蛋白E综合征患者血浆免疫球蛋白E结合因子对人免疫球蛋白E合成的增强作用。
J Clin Invest. 1986 Mar;77(3):952-7. doi: 10.1172/JCI112395.
5
cDNA clones encoding murine IgE-binding factors represent multiple structural variants of intracisternal A-particle genes.编码小鼠IgE结合因子的cDNA克隆代表了脑内A颗粒基因的多种结构变体。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6583-7. doi: 10.1073/pnas.83.17.6583.
6
Nucleotide sequence of a complete mouse intracisternal A-particle genome: relationship to known aspects of particle assembly and function.完整的小鼠脑内A粒子基因组的核苷酸序列：与粒子组装和功能已知方面的关系。
J Virol. 1987 Oct;61(10):3020-9. doi: 10.1128/JVI.61.10.3020-3029.1987.
7
Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor.编码人淋巴细胞IgE受体的cDNA的克隆与表达
EMBO J. 1987 Jan;6(1):109-14. doi: 10.1002/j.1460-2075.1987.tb04726.x.
8
Potentiating and suppressive IgE-binding factors are expressed by a single cloned gene.增强性和抑制性IgE结合因子由单一克隆基因表达。
Proc Natl Acad Sci U S A. 1987 Feb;84(3):809-13. doi: 10.1073/pnas.84.3.809.
9
Nucleotide sequence of the intracisternal A-particle genome inserted 5' to the interleukin-3 gene of the leukemia cell line WEHI-3B.插入白血病细胞系WEHI-3B白细胞介素-3基因5'端的脑内A颗粒基因组的核苷酸序列。
Nucleic Acids Res. 1986 Jul 25;14(14):5901-18. doi: 10.1093/nar/14.14.5901.
10
Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.人和大鼠肥大细胞高亲和力免疫球蛋白E受体：假定α链基因产物的特性
Proc Natl Acad Sci U S A. 1988 Mar;85(6):1907-11. doi: 10.1073/pnas.85.6.1907.
本文引用的文献
1
Formation of rat IgE-binding factors by rat-mouse T cell hybridomas.大鼠-小鼠T细胞杂交瘤产生大鼠IgE结合因子。
J Immunol. 1982 Aug;129(2):509-14.
2
3
4
5
Lymphocytes bearing Fc receptors for IgE. IV. Formation of IgE-binding factor by rat T lymphocytes.带有IgE Fc受体的淋巴细胞。IV. 大鼠T淋巴细胞形成IgE结合因子。
J Immunol. 1980 Mar;124(3):1322-9.
6
7
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha.细胞类型特异性cDNA探针与小鼠I区：Adα的定位与方向
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2194-8. doi: 10.1073/pnas.81.7.2194.
8
Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.一个在猴细胞中表达肥大细胞生长因子活性的小鼠cDNA克隆的分离与鉴定。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1070-4. doi: 10.1073/pnas.81.4.1070.
9
Expression of genes in yeast using the ADCI promoter.使用ADCI启动子在酵母中进行基因表达。
Methods Enzymol. 1983;101:192-201. doi: 10.1016/0076-6879(83)01014-9.
10
Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.人类成人T细胞白血病病毒：整合于白血病细胞DNA中的前病毒基因组的完整核苷酸序列。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3618-22. doi: 10.1073/pnas.80.12.3618.
Zotero 插件