插入白血病细胞系WEHI-3B白细胞介素-3基因5'端的脑内A颗粒基因组的核苷酸序列。
Nucleotide sequence of the intracisternal A-particle genome inserted 5' to the interleukin-3 gene of the leukemia cell line WEHI-3B.
作者信息
Ymer S, Tucker W Q, Campbell H D, Young I G
出版信息
Nucleic Acids Res. 1986 Jul 25;14(14):5901-18. doi: 10.1093/nar/14.14.5901.
Abstract
The nucleotide sequence of the intracisternal A-particle genome IAP-IL3 is presented. This IAP element was found to have inserted upstream of the promoter of the interleukin-3 gene of the leukemia cell line WEHI-3B. IAP-IL3 is 5095 bp in length, with identical long terminal repeats (LTRs) of 337 bp. The LTRs show many of the conserved sequence elements identified in other retroviruses. Comparison with other available sequences of IAP genomes indicates that IAP-IL3 is a deleted type I element. It carries a deletion covering the 3' end of the putative IAP gag gene and extending into the 5' end of the putative IAP pol gene. IAP-IL3 has extensive sequence homology with an IgE-binding factor cDNA and evidence is presented indicating that it was derived from a member of the mouse IAP sequence family. Comparison between the pol region of IAP-IL3 and other retroviruses suggests that IAP-IL3 is most closely related to type B and type D retroviruses.
摘要
本文展示了脑池内A颗粒基因组IAP-IL3的核苷酸序列。发现该IAP元件插入到白血病细胞系WEHI-3B白细胞介素-3基因启动子的上游。IAP-IL3长度为5095 bp，具有长度为337 bp的相同长末端重复序列（LTR）。这些LTR显示出在其他逆转录病毒中鉴定出的许多保守序列元件。与IAP基因组的其他可用序列进行比较表明，IAP-IL3是一种缺失型I元件。它携带一个缺失，覆盖推定的IAP gag基因的3'末端并延伸到推定的IAP pol基因的5'末端。IAP-IL3与一种IgE结合因子cDNA具有广泛的序列同源性，并且有证据表明它源自小鼠IAP序列家族的一个成员。IAP-IL3的pol区域与其他逆转录病毒之间的比较表明，IAP-IL3与B型和D型逆转录病毒关系最为密切。
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