Rao Rohan, Mohammed Caroline, Alschuler Lise, Pomeranz Krummel Daniel A, Sengupta Soma
Department of Neurology & Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Cancers (Basel). 2024 May 6;16(9):1786. doi: 10.3390/cancers16091786.
Modern chemotherapies offer a broad approach to cancer treatment but eliminate both cancer and non-cancer cells indiscriminately and, thus, are associated with a host of side effects. Advances in precision oncology have brought about new targeted therapeutics, albeit mostly limited to a subset of patients with an actionable mutation. They too come with side effects and, ultimately, 'self-resistance' to the treatment. There is recent interest in the modulation of ion channels, transmembrane proteins that regulate the flow of electrically charged molecules in and out of cells, as an approach to aid treatment of cancer. Phytochemicals have been shown to act on ion channels with high specificity regardless of the tumor's genetic profile. This paper explores the use of phytochemicals in cancer symptom management and treatment.
现代化疗为癌症治疗提供了一种广泛的方法，但会不加区分地消灭癌细胞和非癌细胞，因此会产生一系列副作用。精准肿瘤学的进展带来了新的靶向治疗方法，尽管大多仅限于一部分有可操作突变的患者。这些治疗方法也有副作用，最终还会产生对治疗的“自身抗性”。最近，人们对调节离子通道产生了兴趣，离子通道是调节带电分子进出细胞流动的跨膜蛋白，以此作为辅助癌症治疗的一种方法。已证明植物化学物质能以高度特异性作用于离子通道，而与肿瘤的基因特征无关。本文探讨了植物化学物质在癌症症状管理和治疗中的应用。
