Burbaitė Evelina, Čechovičienė Sandra, Sarapinienė Ieva, Karvelienė Birutė, Riškevičienė Vita, Daunoras Gintaras, Juodžentė Dalia
Dr. L. Kriaučeliūnas Small Animal Clinic, Faculty of Veterinary, Veterinary Academy, Lithuanian University of Health Sciences, Tilžės str 18, 44307 Kaunas, Lithuania.
Neurology and Neurosurgery Division, San Marco Veterinary Clinic, 35030 Veggiano, Italy.
Animals (Basel). 2024 Apr 30;14(9):1349. doi: 10.3390/ani14091349.
Oxidative stress (OS) is caused by an imbalance between the production of oxygen-containing free radicals and their elimination. General anesthesia increases the production of reactive oxygen species (ROS) and therefore causes oxidative stress. Our objective was to determine the effects of medetomidine-butorphanol (MEDBUT) and medetomidine-buprenorphine (MEDBUP) on oxidative stress and cardiorespiratory parameters in dogs undergoing ovariohysterectomy (OHE). Ten healthy female dogs were randomly assigned to two groups: the MEDBUT group ( = 5) received medetomidine and butorphanol, while the MEDBUP group ( = 5) received medetomidine and buprenorphine. OS was evaluated by measuring total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) during five different time points (from the administration of anesthetic drugs to 2 h after surgery). The observed vital cardiorespiratory parameters included heart rate (HR), respiratory rate (fR), noninvasive systolic (SAP) and diastolic (DAP) arterial blood pressures, oxygen saturation (SpO), end-tidal CO (EtCO), and body temperature (BT). Cardiorespiratory parameters were altered at a significantly greater degree in animals sedated with MEDBUT ( < 0.05). The administration of medetomidine-butorphanol was more likely to increase OS parameters, while medetomidine-buprenorphine showed decreased levels of oxidative stress throughout the study.
氧化应激（OS）是由含氧化自由基的产生与清除之间的失衡所致。全身麻醉会增加活性氧（ROS）的产生，从而导致氧化应激。我们的目的是确定美托咪定 - 布托啡诺（MEDBUT）和美托咪定 - 丁丙诺啡（MEDBUP）对接受卵巢子宫切除术（OHE）的犬的氧化应激和心肺参数的影响。将10只健康雌性犬随机分为两组：MEDBUT组（n = 5）接受美托咪定和布托啡诺，而MEDBUP组（n = 5）接受美托咪定和丁丙诺啡。在五个不同时间点（从麻醉药物给药至术后2小时）通过测量总抗氧化状态（TAS）、总氧化状态（TOS）和氧化应激指数（OSI）来评估氧化应激。观察到的重要心肺参数包括心率（HR）、呼吸频率（fR）、无创收缩压（SAP）和舒张压（DAP）、血氧饱和度（SpO）、呼气末二氧化碳（EtCO）和体温（BT）。用MEDBUT镇静的动物心肺参数改变程度明显更大（P < 0.05）。美托咪定 - 布托啡诺的给药更有可能增加氧化应激参数，而在整个研究过程中美托咪定 - 丁丙诺啡显示氧化应激水平降低。
