吸入麻醉下吸氧浓度对犬氧化应激生物标志物的影响。
The effect of inspired oxygen concentration on oxidative stress biomarkers in dogs under inhalation anesthesia.
机构信息
The United Graduate School of Veterinary Science, Gifu University, Yanagido 1-1, Gifu, Gifu, 501-1193, Japan (Chongphaibulpatana); Laboratory of Veterinary Diagnostic Radiology, The Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Ueda-cho, Morioka, Iwate, 020-8550, Japan (Chongphaibulpatana, Kumagai, Katayama, Uzuka); Laboratory of Small Animal Surgery, The Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Ueda-cho, Morioka, Iwate, 020-8550, Japan (Fukui).
出版信息
Can J Vet Res. 2020 Apr;84(2):91-95.
This study investigated oxidative stress biomarkers at 3 different oxygen concentrations in dogs under general anesthesia to determine whether high-concentration oxygen increases oxidative stress. Six healthy beagles were randomly assigned to receive 3 anesthesia protocols (inhalation of 40%, 60%, and 100% oxygen) during 3 hours of general anesthesia with sevoflurane, with at least one week in between each protocol. For each experiment, blood samples were collected at 0, 3, 6, and 24 hours after inhalation of oxygen. Derivatives of reactive oxygen metabolites, biochemical antioxidant potential, superoxide dismutase, and 8-hydroxydeoxyguanosine in the blood did not significantly differ among the 3 groups at any time point. This study is the first comparing high concentrations of oxygen with low concentrations of oxygen for anesthesia in dogs. According to our findings, 100% oxygen may not alter the oxidative stress level in dogs during general anesthesia with sevoflurane for 3 hours.
本研究调查了全麻下犬在 3 种不同氧浓度下的氧化应激生物标志物，以确定高浓度氧是否会增加氧化应激。6 只健康的比格犬随机分为 3 组，分别接受 3 小时七氟醚全麻吸入 40%、60%和 100%氧气，每组之间至少间隔 1 周。每组实验中，在吸入氧气后 0、3、6 和 24 小时采集血样。在任何时间点，3 组血液中活性氧代谢物的衍生物、生化抗氧化能力、超氧化物歧化酶和 8-羟基脱氧鸟苷均无显著差异。本研究是首次比较高浓度氧和低浓度氧在犬麻醉中的应用。根据我们的发现，在 3 小时七氟醚全麻期间，100%氧气可能不会改变犬的氧化应激水平。
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