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铜基金属-有机框架衍生的介孔硫化铜纳米材料作为纳米酶用于比色法检测谷胱甘肽。

Cu-BTC Derived Mesoporous CuS Nanomaterial as Nanozyme for Colorimetric Detection of Glutathione.

机构信息

School of Basic Medicine, Shenyang Medical College, Shenyang 110034, China.

Department of Science and Technology, Shenyang Medical College, Shenyang 110034, China.

出版信息

Molecules. 2024 May 3;29(9):2117. doi: 10.3390/molecules29092117.

DOI:10.3390/molecules29092117
PMID:38731608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11085296/
Abstract

In this paper, Cu-BTC derived mesoporous CuS nanomaterial (m-CuS) was synthesized via a two-step process involving carbonization and sulfidation of Cu-BTC for colorimetric glutathione detection. The Cu-BTC was constructed by 1,3,5-benzenetri-carboxylic acid (HBTC) and Cu ions. The obtained m-CuS showed a large specific surface area (55.751 m/g), pore volume (0.153 cm/g), and pore diameter (15.380 nm). In addition, the synthesized m-CuS exhibited high peroxidase-like activity and could catalyze oxidation of the colorless substrate 3,3',5,5'-tetramethylbenzidine to a blue product. Peroxidase-like activity mechanism studies using terephthalic acid as a fluorescent probe proved that m-CuS assists HO decomposition to reactive oxygen species, which are responsible for TMB oxidation. However, the catalytic activity of m-CuS for the oxidation of TMB by HO could be potently inhibited in the presence of glutathione. Based on this phenomenon, the colorimetric detection of glutathione was demonstrated with good selectivity and high sensitivity. The linear range was 1-20 μM and 20-300 μM with a detection limit of 0.1 μM. The m-CuS showing good stability and robust peroxidase catalytic activity was applied for the detection of glutathione in human urine samples.

摘要

本文通过碳化和硫化 Cu-BTC 的两步法合成了介孔 CuS 纳米材料（m-CuS），用于比色谷胱甘肽检测。Cu-BTC 由 1,3,5-苯三甲酸（HBTC）和 Cu 离子构建。所得的 m-CuS 具有大的比表面积（55.751 m/g）、孔体积（0.153 cm/g）和孔径（15.380 nm）。此外，合成的 m-CuS 表现出高过氧化物酶样活性，可以催化无色底物 3,3',5,5'-四甲基联苯胺氧化为蓝色产物。使用对苯二甲酸作为荧光探针的过氧化物酶样活性机制研究证明，m-CuS 有助于 HO 分解产生活性氧，这些活性氧负责 TMB 的氧化。然而，谷胱甘肽的存在可以强烈抑制 m-CuS 对 HO 氧化 TMB 的催化活性。基于这一现象，实现了谷胱甘肽的比色检测，具有良好的选择性和高灵敏度。线性范围为 1-20 μM 和 20-300 μM，检测限为 0.1 μM。m-CuS 表现出良好的稳定性和稳健的过氧化物酶催化活性，可用于检测人尿样中的谷胱甘肽。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/766442161efe/molecules-29-02117-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/0d0c3be2abd3/molecules-29-02117-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/e12e1be52f25/molecules-29-02117-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/c4b346a3de6a/molecules-29-02117-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/955175df466d/molecules-29-02117-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/51d51a6f501d/molecules-29-02117-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/5596ef53a42c/molecules-29-02117-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/d113dc1bea47/molecules-29-02117-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/92428cad8469/molecules-29-02117-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/766442161efe/molecules-29-02117-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/0d0c3be2abd3/molecules-29-02117-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/e12e1be52f25/molecules-29-02117-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/c4b346a3de6a/molecules-29-02117-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/955175df466d/molecules-29-02117-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/51d51a6f501d/molecules-29-02117-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/5596ef53a42c/molecules-29-02117-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/d113dc1bea47/molecules-29-02117-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/92428cad8469/molecules-29-02117-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38b9/11085296/766442161efe/molecules-29-02117-g009.jpg

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本文引用的文献

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A novel CRISPR/Cas14a-based electrochemical biosensor for ultrasensitive detection of Burkholderia pseudomallei with PtPd@PCN-224 nanoenzymes for signal amplification.一种基于新型 CRISPR/Cas14a 的电化学生物传感器，用于超灵敏检测伯克霍尔德菌假单胞菌，采用 PtPd@PCN-224 纳米酶进行信号放大。
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