Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Molecules. 2024 May 5;29(9):2143. doi: 10.3390/molecules29092143.
Cellular slime molds are excellent model organisms in the field of cell and developmental biology because of their simple developmental patterns. During our studies on the identification of bioactive molecules from secondary metabolites of cellular slime molds toward the development of novel pharmaceuticals, we revealed the structural diversity of secondary metabolites. Cellular slime molds grow by feeding on bacteria, such as and without using medium components. Although changing the feeding bacteria is expected to affect dramatically the secondary metabolite production, the effect of the feeding bacteria on the production of secondary metabolites is not known. Herein, we report the isolation and structure elucidation of clavapyrone () from , intermedipyrone () from , and magnumiol () from . These compounds are not obtained from usual cultural conditions with but obtained from coincubated conditions with spp. The results demonstrate the diversity of the secondary metabolites of cellular slime molds and suggest that widening the range of feeding bacteria for cellular slime molds would increase their application potential in drug discovery.
细胞黏菌是细胞和发育生物学领域的优秀模式生物，因为它们具有简单的发育模式。在我们研究从细胞黏菌的次生代谢产物中鉴定生物活性分子以开发新型药物的过程中，我们揭示了次生代谢产物的结构多样性。细胞黏菌通过以细菌（如 和 ）为食来生长，而不使用培养基成分。尽管改变饲养细菌预计会极大地影响次生代谢产物的产生，但饲养细菌对次生代谢产物产生的影响尚不清楚。在此，我们报道了从 中分离得到的clavapyrone()、从 中分离得到的intermedipyrone()和从 中分离得到的magnumiol()。这些化合物不是从通常使用 培养的条件下获得的，而是从与 spp 共培养的条件下获得的。这些结果表明细胞黏菌的次生代谢产物具有多样性，并表明拓宽细胞黏菌的饲养细菌范围将增加它们在药物发现中的应用潜力。
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