Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Graduate School of Health and Sports Science, Juntendo University, 1-1 Hiraga-gakuendai, Inzai, Chiba 270-1695, Japan.
Molecules. 2020 Jun 23;25(12):2895. doi: 10.3390/molecules25122895.
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.
我们从细胞黏菌中分离得到一种原贝壳杉烷型倍半萜、粘帚菌素醇，以及一种香叶基双环倍半萜、深绿木霉菌，它们的结构通过多种光谱方法确定。尽管粘帚菌素醇显示出非常弱的细胞增殖抑制活性，但它表现出适度的破骨细胞分化抑制活性。因此，细胞黏菌产生相当多样化的次生代谢产物，它们是新天然产物化学的有前途的来源。
