Matana Kaštelan Zrinka, Brumini Ivan, Poropat Goran, Tkalčić Lovro, Grubešić Tiana, Miletić Damir
Department of Diagnostic and Interventional Radiology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
Department of Anatomy, Faculty of Medicine of the University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia.
Diagnostics (Basel). 2024 May 2;14(9):955. doi: 10.3390/diagnostics14090955.
The aim of our study was to investigate iodine density (ID) and fat fraction (FF) on dual-energy computed tomography (DECT) in patients with acute pancreatitis (AP). This retrospective study included 72 patients with clinically confirmed AP and 62 control subjects with DECT of the abdomen. Two radiologists assessed necrosis and measured attenuation values, ID, and FF in three pancreatic segments. We used receiver operating characteristic (ROC) analysis to determine the optimal threshold for ID for the differentiation between AP groups. The ID was significantly higher in interstitial edematous AP compared to necrotizing AP and the control group (both < 0.05). The ROC curve analysis revealed the thresholds of ID for detecting pancreatic necrosis ≤ 2.2, ≤2.3, and ≤2.4 mg/mL (AUC between 0.880 and 0.893, > 0.05) for the head, body, and tail, respectively. The FF was significantly higher for pancreatitis groups when compared with the control group in the head and body segments (both < 0.001). In the tail, the difference was significant in necrotizing AP ( = 0.028). The ID values were independent of attenuation values correlated with the FF values in pancreatic tissue. Iodine density values allow for differentiation between morphologic types of AP.
我们研究的目的是利用双能计算机断层扫描（DECT）研究急性胰腺炎（AP）患者的碘密度（ID）和脂肪分数（FF）。这项回顾性研究纳入了72例临床确诊的AP患者和62例接受腹部DECT检查的对照受试者。两名放射科医生评估胰腺坏死情况，并测量三个胰腺节段的衰减值、ID和FF。我们采用受试者操作特征（ROC）分析来确定区分AP组的ID最佳阈值。与坏死性AP和对照组相比，间质性水肿性AP的ID显著更高（均P<0.05）。ROC曲线分析显示，检测胰腺坏死时，胰头、胰体和胰尾的ID阈值分别为≤2.2、≤2.3和≤2.4 mg/mL（AUC在0.880至0.893之间，P>0.05）。胰腺炎组胰头和胰体节段的FF显著高于对照组（均P<0.001）。在胰尾，坏死性AP的差异有统计学意义（P=0.028）。ID值与胰腺组织中与FF值相关的衰减值无关。碘密度值有助于区分AP的形态学类型。
