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智能肝功能检测(iLFT):一种识别慢性肝病的智能实验室方法。

Intelligent Liver Function Testing (iLFT): An Intelligent Laboratory Approach to Identifying Chronic Liver Disease.

作者信息

Nobes Jennifer, Leith Damien, Handjiev Sava, Dillon John F, Dow Ellie

机构信息

Department of Blood Sciences, NHS Tayside, Ninewells Hospital, Dundee DD1 9SY, UK.

Population Health & Genomics, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.

出版信息

Diagnostics (Basel). 2024 May 4;14(9):960. doi: 10.3390/diagnostics14090960.

DOI:10.3390/diagnostics14090960
PMID:38732374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11083526/
Abstract

The intelligent Liver Function Testing (iLFT) pathway is a novel, algorithm-based system which provides automated laboratory investigations and clinical feedback on abnormal liver function test (LFT) results from primary care. iLFT was introduced to NHS Tayside, Scotland, in August 2018 in response to vast numbers of abnormal LFTs, many of which were not appropriately investigated, coupled with rising mortality from chronic liver disease. Here, we outline the development and implementation of the iLFT pathway, considering the implications for the diagnostic laboratories, primary care services and specialist hepatology clinics. Additionally, we describe the utility, outcomes and evolution of iLFT, which was used over 11,000 times in its first three years alone. Finally, we will consider the future of iLFT and propose areas where similar 'intelligent' approaches could be used to add value to laboratory investigations.

摘要

智能肝功能检测(iLFT)路径是一种新型的、基于算法的系统,它能对基层医疗中异常肝功能检测(LFT)结果提供自动实验室检查及临床反馈。iLFT于2018年8月引入苏格兰泰赛德国民保健服务体系(NHS Tayside),以应对大量异常的肝功能检测结果(其中许多未得到适当检查)以及慢性肝病死亡率上升的问题。在此,我们概述了iLFT路径的开发与实施情况,考量其对诊断实验室、基层医疗服务及专科肝病诊所的影响。此外,我们描述了iLFT的效用、成果及发展,仅在其投入使用的头三年里,它就被使用了超过11000次。最后,我们将思考iLFT的未来,并提出可采用类似“智能”方法为实验室检查增添价值的领域。

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JHEP Rep. 2024 Mar 11;6(6):101062. doi: 10.1016/j.jhepr.2024.101062. eCollection 2024 Jun.
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Nat Rev Gastroenterol Hepatol. 2024 Jul;21(7):517-527. doi: 10.1038/s41575-024-00907-2. Epub 2024 Mar 13.
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