Hahn H, Kuhring D, Trautmann M, Diamantstein T
Arzneimittelforschung. 1985;35(2):543-6.
The influence of the orally applicable antibacterial agents, cefaclor (Panoral), doxycycline, erythromycin, and cotrimoxazole on phagocytosis by human neutrophil granulocytes was investigated. Further, the influence of cefaclor, erythromycin, and doxycycline on PHA stimulation of human blood lymphocytes was studied. Doxycycline (1 mg/ml) had strongly suppressive effects on phagocytosis, whereas cefaclor (1 mg/ml cotrimoxazole (0.1 mg/ml), and erythromycin (0.1 mg/ml) did not suppress phagocytosis. PHA-induced lymphocyte stimulation was strongly inhibited by doxycycline (10 micrograms/ml), whereas cefaclor (10 micrograms/ml) did not suppress at all. Erythromycin (10 micrograms/ml) exerted some inhibition (average 12.6%). These results are discussed with respect to immunoneutrality of antibacterial agents.
研究了口服抗菌剂头孢克洛（泛福舒）、强力霉素、红霉素和复方新诺明对人中性粒细胞吞噬作用的影响。此外，还研究了头孢克洛、红霉素和强力霉素对人血淋巴细胞PHA刺激的影响。强力霉素（1毫克/毫升）对吞噬作用有强烈的抑制作用，而头孢克洛（1毫克/毫升）、复方新诺明（0.1毫克/毫升）和红霉素（0.1毫克/毫升）则不抑制吞噬作用。强力霉素（10微克/毫升）强烈抑制PHA诱导的淋巴细胞刺激，而头孢克洛（10微克/毫升）则完全不抑制。红霉素（10微克/毫升）有一定的抑制作用（平均12.6%）。就抗菌剂的免疫中性对这些结果进行了讨论。
