Department Obstetrics and Gynecology, Faculty of Medicine, University of Padjadjaran - Dr. Hasan Sadikin General Hospital Bandung, Bandung, West Java, Indonesia.
Clinical Clerkship, Faculty of Medicine, University of Padjadjaran - Dr. Hasan Sadikin General Hospital Bandung, Bandung, West Java, Indonesia.
Med Sci Monit. 2024 May 11;30:e943895. doi: 10.12659/MSM.943895.
BACKGROUND Preterm birth is one of the main causes of neonatal death worldwide. One strategy focused on preventing preterm birth is the administration of long chain polyunsaturated fatty acids (LCPUFAs) during pregnancy. Omega-3 LCPUFAs, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential in metabolic and physiological processes during embryonic and fetal development. This study aimed to compare DHA and EPA levels in 44 women with preterm births and 44 women with term births at a tertiary hospital in West Java Province, Indonesia, between November 2022 and March 2023. MATERIAL AND METHODS A total of 88 patients in this study consisted of 44 patients with term births (≥37 gestational weeks) and 44 patients with preterm births (<37 gestational weeks) at a tertiary hospital in West Java Province, Indonesia. This observational, cross-sectional study was conducted from November 2022 to March 2023. Using the enzyme-linked immunosorbent assay test, maternal DHA and EPA levels were investigated. IBM SPSS 24.0 was used to statistically measure outcomes. RESULTS Average maternal DHA and EPA levels in patients with preterm births were significantly lower than those in term births. Preterm labor risk was further increased by DHA levels of ≤5.70 µg/mL (OR=441.00, P=0.000) and EPA levels ≤3971.54 µg/mL (OR=441.00, P=0.000). CONCLUSIONS Since the average maternal DHA and EPA levels were significantly lower in patients with preterm births, adequate intake of omega-3 LCPUFA in early pregnancy and consistency with existing nutritional guidelines was associated with a lower risk of preterm delivery for pregnant women.
早产是全球新生儿死亡的主要原因之一。预防早产的策略之一是在怀孕期间给予长链多不饱和脂肪酸（LCPUFAs）。ω-3 LCPUFAs，包括二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），在胚胎和胎儿发育的代谢和生理过程中是必不可少的。本研究旨在比较印度尼西亚西爪哇省一家三级医院 44 例早产妇女和 44 例足月分娩妇女的 DHA 和 EPA 水平。
本研究共有 88 例患者，包括印度尼西亚西爪哇省一家三级医院的 44 例足月分娩（≥37 孕周）和 44 例早产（<37 孕周）患者。这是一项观察性、横断面研究，于 2022 年 11 月至 2023 年 3 月进行。采用酶联免疫吸附试验检测产妇 DHA 和 EPA 水平。使用 IBM SPSS 24.0 对结果进行统计学测量。
早产患者的平均母体 DHA 和 EPA 水平明显低于足月分娩患者。DHA 水平≤5.70 µg/mL（OR=441.00，P=0.000）和 EPA 水平≤3971.54 µg/mL（OR=441.00，P=0.000）时早产风险进一步增加。
由于早产患者的平均母体 DHA 和 EPA 水平明显较低，因此孕妇在妊娠早期摄入足够的ω-3 LCPUFA 并遵循现有的营养指南与降低早产风险有关。
