Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia.
Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia.
Sci Rep. 2021 Jul 19;11(1):14701. doi: 10.1038/s41598-021-93846-w.
Long-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16-25.42 and preterm birth with OR 4.68, 95%CI 1.52-14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status.
长链多不饱和脂肪酸（LCPUFA）在整个怀孕期间都是必不可少的，因为 LPUFA 的缺乏可能与产科并发症有关。本研究旨在调查严重子痫前期和早产中 LCPUFA 的状况。对 104 名孕妇进行了横断面研究，分为正常妊娠、严重子痫前期和早产组。采用气相色谱/质谱法测定血清总 LCPUFA、ω-3、α-亚麻酸（ALA）、二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）、ω-6、亚油酸（LA）和花生四烯酸（AA）的百分比和浓度。进行了接收器操作特征（ROC）、双变量和多变量分析。与对照组相比，严重子痫前期显示出最高的总多不饱和脂肪酸浓度和最低的 DHA 百分比，且 Omega-6/Omega-3 比值显著更高（p=0.004），ω-3 指数显著更低（p<0.002）。早产显示出最低的 ω-3 浓度，与对照组相比，ω-6 衍生物（LA（p=0.014）和 AA（p=0.025））显著降低。LCPUFA 参数表明两种情况的风险增加，特别是子痫前期中 ALA≤53µmol/L 的 OR 为 5.44，95%CI 为 1.16-25.42，早产的 OR 为 4.68，95%CI 为 1.52-14.38。这些发现表明严重子痫前期和早产存在 LCPUFA 状态失衡。
