Martina's Children's Hospital, Stockholm, Sweden.
Division of Paediatric Oncology and Surgery, Department of Women's and Children's Health and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Acta Paediatr. 2024 Aug;113(8):1949-1956. doi: 10.1111/apa.17270. Epub 2024 May 11.
To assess testicular volume at puberty for boys who underwent orchidopexy at 9 or at 36 months compared to boys with spontaneous postnatal descent.
At age 6 months, boys with congenital unilateral cryptorchidism were randomised to surgery at 9 or 39 months of age and followed to 16 years in parallel with boys with spontaneous postnatal descent. Ultrasound was done at 11 and 16 years to determine testicular volume. The ratio of the initially undescended testis to its scrotal counterpart was used to assess testicular growth.
At age 16, the ratio was lower (p < 0.00) in the late group compared to the early group. At 16 years, the spontaneously descended testes were significantly smaller than their scrotal counterparts but larger than the operated groups (early p < 0.01 and late p < 0.00).
Our data at 16 years show that orchidopexy at 9 months results in better testicular growth compared to 3 years but did not reach the corresponding volumes of their scrotal counterparts. This indicates that earlier surgery is beneficial to testicular growth. At age 16, the postnatally descended testes were not only larger than the surgically treated testes but also exhibited impaired testicular growth.
评估 9 个月和 36 个月行睾丸固定术与自发性出生后下降的男孩在青春期睾丸体积。
6 月龄患有先天性单侧隐睾的男孩随机分为 9 个月或 39 个月手术，并在 16 岁时与自发性出生后下降的男孩进行平行随访。在 11 岁和 16 岁时进行超声检查以确定睾丸体积。未降睾丸与其阴囊对应物的比值用于评估睾丸生长。
在 16 岁时，晚期组的比值较低（p<0.00）。16 岁时，自发性下降的睾丸明显小于其阴囊对应物，但大于手术组（早期 p<0.01 和晚期 p<0.00）。
我们在 16 岁时的数据显示，9 个月时行睾丸固定术比 3 岁时睾丸生长更好，但未达到相应的阴囊体积。这表明早期手术有利于睾丸生长。在 16 岁时，出生后下降的睾丸不仅大于手术治疗的睾丸，而且还表现出受损的睾丸生长。
