Zheng Qiuyang, Wang Xin
Shenzhen Research Institute of Xiamen University, Shenzhen 518057, China.
State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Department of Neurology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361005, China.
Protein Cell. 2025 Feb 1;16(2):83-120. doi: 10.1093/procel/pwae026.
Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositions, the development of AD is influenced by a myriad of risk factors, including aging, systemic inflammation, chronic health conditions, lifestyle, and environmental exposures. Recent advancements in understanding the complex pathophysiology of AD are paving the way for enhanced diagnostic techniques, improved risk assessment, and potentially effective prevention strategies. These discoveries are crucial in the quest to unravel the complexities of AD, offering a beacon of hope for improved management and treatment options for the millions affected by this debilitating disease.
阿尔茨海默病（AD）是痴呆的主要病因，其特征是大脑中出现淀粉样斑块和神经原纤维缠结。由于其复杂的多因素性质，这种疾病给全球健康带来了巨大影响。除了遗传易感性外，AD的发展还受到众多风险因素的影响，包括衰老、全身炎症、慢性健康状况、生活方式和环境暴露。在理解AD复杂病理生理学方面的最新进展为增强诊断技术、改进风险评估以及潜在的有效预防策略铺平了道路。这些发现对于解开AD的复杂性至关重要，为改善数百万受这种致残性疾病影响者的管理和治疗选择带来了希望之光。
