Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Pathology, University of Miami, Miami, Florida.
Mod Pathol. 2024 Aug;37(8):100512. doi: 10.1016/j.modpat.2024.100512. Epub 2024 May 9.
This review focuses on mature T cells, natural killer (NK) cells, and stroma-derived neoplasms in the fifth edition of the World Health Organization classification of hematolymphoid tumors, including changes from the revised fourth edition. Overall, information has expanded, primarily due to advancements in genomic understanding. The updated classification adopts a hierarchical format. The updated classification relies on a multidisciplinary approach, incorporating insights from a diverse group of pathologists, clinicians, and geneticists. Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract, Epstein-Barr virus-positive nodal T- and NK-cell lymphoma, and several stroma-derived neoplasms of lymphoid tissues have been newly introduced or included. The review also provides guidance on how the fifth edition of the World Health Organization classification of hematolymphoid tumors can be applied in routine clinical practice.
这篇综述聚焦于第五版世界卫生组织血液淋巴组织肿瘤分类中的成熟 T 细胞、自然杀伤 (NK) 细胞和基质衍生性肿瘤，包括与修订后的第四版相比的变化。总体而言，信息有所扩展，主要是由于对基因组理解的进步。更新的分类采用了分层格式。更新的分类依赖于多学科方法，结合了来自不同病理学家、临床医生和遗传学家的见解。新引入或包括了几种胃肠道惰性 NK 细胞淋巴增生性疾病、EB 病毒阳性结内 T/NK 细胞淋巴瘤和一些淋巴组织基质衍生性肿瘤。该综述还提供了关于如何在常规临床实践中应用第五版世界卫生组织血液淋巴组织肿瘤分类的指导。
