Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester , MN , USA.
Department of Surgical Pathology, Aichi Medical University Hospital , Nagakute , Aichi , Japan.
Expert Rev Hematol. 2019 Oct;12(10):833-843. doi: 10.1080/17474086.2019.1647777. Epub 2019 Jul 31.
: The classification of lymphomas is based on the postulated normal counterparts of lymphoid neoplasms and currently constitutes over 100 definite or provisional entities. As this number of entities implies, lymphomas show marked pathological, genetic, and clinical heterogeneity. Recent molecular findings have significantly advanced our understanding of lymphomas. : The World Health Organization (WHO) classification of lymphoid neoplasms was updated in 2017. The present review summarizes the new findings that have been gained in the areas of mature T-cell neoplasms, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms since the publication of the 2017 WHO classification. : Although formal revisions to the WHO classification are published only periodically, our understanding of the pathologic, genetic, and clinical features of lymphoid neoplasms is constantly evolving, particularly in the age of -omics technologies and targeted therapeutics. Even in the relatively short time since the publication of the 2017 WHO classification, many significant findings have been identified in the entities covered in this review.
: 淋巴瘤的分类基于淋巴肿瘤的假定正常对应物,目前包括 100 多种明确或暂定的实体。由于实体数量众多,淋巴瘤表现出明显的病理、遗传和临床异质性。最近的分子发现显著提高了我们对淋巴瘤的认识。
: 世界卫生组织(WHO)于 2017 年更新了淋巴肿瘤分类。本综述总结了自 2017 年 WHO 分类发布以来,在成熟 T 细胞肿瘤、霍奇金淋巴瘤和组织细胞/树突状细胞肿瘤领域获得的新发现。
: 尽管只有定期发布正式的 WHO 分类修订版,但我们对淋巴肿瘤的病理、遗传和临床特征的认识一直在不断发展,特别是在组学技术和靶向治疗的时代。即使在 2017 年 WHO 分类发布后的相对较短时间内,本综述涵盖的实体中也发现了许多重要的发现。