Millar B C, Jinks S
Int J Radiat Biol Relat Stud Phys Chem Med. 1985 May;47(5):539-52. doi: 10.1080/09553008514550771.
A 20 h pre-treatment of human cells from normal (foetal lung) or malignant origin (glioma, lines U118 MG and U251 MG and bladder carcinoma, line EJ) with dexamethasone failed to increase their radiation resistance in vitro despite a 2-fold increase in the GSH content of a glioma cell line, U251 MG, and a small but significant increase in the GSH content of EJ bladder carcinoma cells. In contrast, there was a correlation between an increase in radiation resistance and an elevated GSH content of rodent cells (Chinese hamster lung, line V-79-379A; ovary, line CHO; rat hepatoma, line HTC, and mouse neuroblastoma, line NB413A) after a similar pre-treatment. The results suggest that enhancement of radiation resistance cannot be directly ascribed to an elevated GSH content in steroid-treated cells. On the basis of these data it is unlikely that the efficacy of radiotherapy will be diminished amongst patients receiving concomitant treatment with dexamethasone. However, in vivo testing is required to confirm these findings.
用 dexamethasone 对来自正常（胎儿肺）或恶性来源（胶质瘤，U118 MG 和 U251 MG 细胞系；膀胱癌，EJ 细胞系）的人类细胞进行 20 小时预处理，尽管胶质瘤细胞系 U251 MG 的谷胱甘肽（GSH）含量增加了 2 倍，EJ 膀胱癌细胞的 GSH 含量有小幅但显著的增加，但体外实验中这些细胞的辐射抗性并未提高。相反，经过类似预处理后，啮齿动物细胞（中国仓鼠肺，V - 79 - 379A 细胞系；卵巢，CHO 细胞系；大鼠肝癌，HTC 细胞系；小鼠神经母细胞瘤，NB413A 细胞系）的辐射抗性增加与 GSH 含量升高之间存在相关性。结果表明，辐射抗性的增强不能直接归因于类固醇处理细胞中 GSH 含量的升高。基于这些数据，接受 dexamethasone 联合治疗的患者放疗疗效不太可能降低。然而，需要进行体内试验来证实这些发现。
