Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Smart Gym-Based Translational Research Center for Active Senior's Healthcare, Pukyong National University, Busan 48513, Republic of Korea.
Acta Biomater. 2024 Jul 1;182:213-227. doi: 10.1016/j.actbio.2024.05.008. Epub 2024 May 10.
The strategic integration of multi-functionalities within a singular nanoplatform has received growing attention for enhancing treatment efficacy, particularly in chemo-photothermal therapy. This study introduces a comprehensive concept of Janus nanoparticles (JNPs) composed of Au and FeO nanostructures intricately bonded with β-cyclodextrins (β-CD) to encapsulate 5-Fluorouracil (5-FU) and Ibuprofen (IBU). This strategic structure is engineered to exploit the synergistic effects of chemo-photothermal therapy, underscored by their exceptional biocompatibility and photothermal conversion efficiency (∼32.88 %). Furthermore, these β-CD-conjugated JNPs enhance photodynamic therapy by generating singlet oxygen (O) species, offering a multi-modality approach to cancer eradication. Computer simulation results were in good agreement with in vitro and in vivo assays. Through these studies, we were able to prove the improved tumor ablation ability of the drug-loaded β-CD-conjugated JNPs, without inducing adverse effects in tumor-bearing nude mice. The findings underscore a formidable tumor ablation potency of β-CD-conjugated Au-FeO JNPs, heralding a new era in achieving nuanced, highly effective, and side-effect-free cancer treatment modalities. STATEMENT OF SIGNIFICANCE: The emergence of multifunctional nanoparticles marks a pivotal stride in cancer therapy research. This investigation unveils Janus nanoparticles (JNPs) amalgamating gold (Au), iron oxide (FeO), and β-cyclodextrins (β-CD), encapsulating 5-Fluorouracil (5-FU) and Ibuprofen (IBU) for synergistic chemo-photothermal therapy. Demonstrating both biocompatibility and potent photothermal properties (∼32.88 %), these JNPs present a promising avenue for cancer treatment. Noteworthy is their heightened photodynamic efficiency and remarkable tumor ablation capabilities observed in vitro and in vivo, devoid of adverse effects. Furthermore, computational simulations validate their interactions with cancer cells, bolstering their utility as an emerging therapeutic modality. This endeavor pioneers a secure and efficacious strategy for cancer therapy, underscoring the significance of β-CD-conjugated Au-FeO JNPs as innovative nanoplatforms with profound implications for the advancement of cancer therapy.
Janus 纳米粒子（JNPs）由金（Au）和氧化铁（FeO）纳米结构与β-环糊精（β-CD）复杂键合而成，用于封装 5-氟尿嘧啶（5-FU）和布洛芬（IBU），本文提出了一种综合性概念。该结构设计旨在利用化学-光热协同治疗的协同效应，其具有出色的生物相容性和光热转换效率（约 32.88%）。此外，这些与β-CD 结合的 JNPs 通过生成单线态氧（O）来增强光动力疗法，为癌症消除提供了一种多模态方法。计算机模拟结果与体外和体内实验结果吻合良好。通过这些研究，我们证明了载药β-CD 结合 JNPs 对肿瘤的消融能力得到了提高，而在荷瘤裸鼠中没有引起不良反应。这些结果突出了β-CD 结合的 Au-FeO JNPs 强大的肿瘤消融能力，为实现细致、高效、无副作用的癌症治疗模式开辟了新纪元。
声明意义：多功能纳米粒子的出现标志着癌症治疗研究的一个重要进展。本研究揭示了金（Au）、氧化铁（FeO）和β-环糊精（β-CD）结合的 Janus 纳米粒子（JNPs），用于协同化学-光热治疗，封装 5-氟尿嘧啶（5-FU）和布洛芬（IBU）。这些 JNPs 具有生物相容性和高效的光热性能（约 32.88%），为癌症治疗提供了一种很有前途的途径。值得注意的是，它们在体外和体内观察到增强的光动力效率和显著的肿瘤消融能力，而且没有副作用。此外，计算模拟验证了它们与癌细胞的相互作用，增强了它们作为一种新兴治疗模式的实用性。这项研究开创了一种安全有效的癌症治疗策略，强调了β-CD 结合的 Au-FeO JNPs 作为具有创新性的纳米平台的重要性，对癌症治疗的发展具有深远的意义。
