Professor, Department of Gastroenterology, Sardar Patel Medical College, Bikaner, Rajasthan, India, Corresponding Author.
Professor, Department of Gastroenterology, Sardar Patel Medical College, Bikaner, Rajasthan, India.
J Assoc Physicians India. 2024 Jan;72(1):14-16. doi: 10.59556/japi.71.0432.
In recent years, there has been an alarming increase in cases of gastric outlet obstruction (GOO) at our center due to drug abuse. So, we conducted this study to know the incidence of nonsteroidal anti-inflammatory drugs (NSAIDs) and synthetic opioid abuse in cases of GOO.
This was an observational study involving consecutive cases of GOO diagnosed from September 2017 to February 2019. A detailed history, including drug addiction history and clinical examination, was done. Investigations included routine biochemical and hematological tests, upper gastrointestinal endoscopy (UGIE), ultrasonography, rapid urease test (RUT), and histopathology of the diseased area.
Among the 102 cases diagnosed with GOO, 62 (60.78%) cases had a history of drug addiction. The drug addiction history was as follows: NSAIDs and opioids in 56, opioids alone in four, and NSAIDs alone in two cases. The most common site of stricture was the second part of the duodenum. The features on histopathology were ulcerations of the mucosa infiltrated by eosinophils, plasma cells, and lymphocytes.
There is an alarming increase in the incidence of GOO due to NSAIDs and opioid abuse at our center. Efforts should be made to control the indiscriminate use of these over-the-counter drugs to prevent dreaded complications.
近年来，由于药物滥用，我们中心因胃出口梗阻 (GOO) 而就诊的病例数量惊人地增加。因此，我们进行了这项研究，以了解非甾体抗炎药 (NSAIDs) 和合成阿片类药物滥用在 GOO 病例中的发生率。
这是一项观察性研究，涉及 2017 年 9 月至 2019 年 2 月期间连续诊断为 GOO 的病例。进行了详细的病史，包括药物滥用史和临床检查。检查包括常规生化和血液学检查、上消化道内镜检查 (UGIE)、超声检查、快速尿素酶试验 (RUT) 和患病区域的组织病理学检查。
在诊断为 GOO 的 102 例病例中，有 62 例（60.78%）有药物滥用史。药物滥用史如下：56 例为 NSAIDs 和阿片类药物，4 例为阿片类药物，2 例为 NSAIDs。狭窄最常见的部位是十二指肠第二段。组织病理学特征为黏膜溃疡，浸润有嗜酸性粒细胞、浆细胞和淋巴细胞。
由于 NSAIDs 和阿片类药物滥用，我们中心的 GOO 发病率惊人增加。应努力控制这些非处方药物的滥用，以预防可怕的并发症。
