Weaver G A, Harper R L, Storey J A, Jenkins P L, Merrell N B
Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, NY 13326-1394, USA.
J Clin Gastroenterol. 1995 Apr;20(3):196-8. doi: 10.1097/00004836-199504000-00006.
Nonsteroidal antiinflammatory drug associated gastric ulcerations are often prepyloric and painless; when recurrent, such ulcers may lead to pyloric scarring and gastric outlet obstruction. We performed a retrospective case control study to seek an association between gastric outlet obstruction and nonsteroidal antiinflammatory drug use. The use of nonsteroidal antiinflammatory drugs in cases with gastric outlet obstruction was compared to an age- and sex-matched outpatient control group undergoing endoscopy. The proportion of drug use by patients with gastric outlet obstruction, seven of nine, was significantly higher than the proportion in controls, 29 of 90. The duration of nonsteroidal antiinflammatory drug use was also significantly longer in patients with gastric outlet obstruction than in control patients. Chronic nonsteroidal antiinflammatory drug use is associated with gastric outlet obstruction.
非甾体抗炎药相关性胃溃疡常位于幽门窦前且无痛；复发时，此类溃疡可能导致幽门瘢痕形成和胃出口梗阻。我们进行了一项回顾性病例对照研究，以探寻胃出口梗阻与非甾体抗炎药使用之间的关联。将胃出口梗阻患者使用非甾体抗炎药的情况与接受内镜检查的年龄和性别匹配的门诊对照组进行比较。胃出口梗阻患者中九分之七使用药物的比例显著高于对照组中90例患者里29例使用药物的比例。胃出口梗阻患者使用非甾体抗炎药的持续时间也显著长于对照患者。长期使用非甾体抗炎药与胃出口梗阻有关。
