Lorzadeh Nahid, Jahanshahi Moghadaseh
Department Obstetrics and Gynecology, Faculty of Medicine Lorestan University of Medical Sciences Khorramabad Iran.
Department of Obstetrics and Gynecology, School of Medicine, Sayyad Shirazi Hospital Golestan University of Medical Sciences Gorgan Iran.
Health Sci Rep. 2024 May 9;7(5):e2091. doi: 10.1002/hsr2.2091. eCollection 2024 May.
This study aims to evaluate the effect of duloxetine on stress urinary incontinence (SUI) episode frequency (IEF) per week IEF.
In this clinical trial, 100 women aged 20-80 years with urinary incontinence were assessed based on the standard questionnaire of urinary tract disorders. All the patients received a placebo for 2 weeks. Patients were then randomly divided into two groups of 50 patients each, receiving duloxetine (40 mg twice a day for 12 weeks) and placebo. The two groups were compared in terms of IEF and the mean score of quality of life and side effects.
The two groups of duloxetine and placebo recipients were matched at the beginning of the study in terms of age, BMI, IEF, parity, and type of delivery. IEF significantly decreased in the duloxetine recipient group compared to the placebo group. The mean score of quality of life in the duloxetine recipient group increased significantly. The rate of study abandonment in the duloxetine recipient group was significantly higher than in the placebo group. Vertigo was the most common complication that caused patients to discontinue the use of the drug.
Duloxetine is therapeutically effective for SUI in women. Patients should be provided information regarding potential side effects and their management.
本研究旨在评估度洛西汀对压力性尿失禁（SUI）每周发作频率（IEF）的影响。
在这项临床试验中，根据尿路疾病标准问卷对100名年龄在20 - 80岁的尿失禁女性进行评估。所有患者接受2周的安慰剂治疗。然后将患者随机分为两组，每组50名，分别接受度洛西汀（每日两次，每次40毫克，共12周）和安慰剂治疗。比较两组的IEF、生活质量平均得分及副作用。
度洛西汀组和安慰剂组在研究开始时在年龄、体重指数、IEF、产次和分娩类型方面相匹配。与安慰剂组相比，度洛西汀组的IEF显著降低。度洛西汀组的生活质量平均得分显著提高。度洛西汀组的研究放弃率显著高于安慰剂组。眩晕是导致患者停药的最常见并发症。
度洛西汀对女性SUI治疗有效。应向患者提供有关潜在副作用及其处理的信息。
