实验性自身免疫性前列腺炎的研究趋势：对发病机制、治疗策略及重新定义的见解
Trends in experimental autoimmune prostatitis: insights into pathogenesis, therapeutic strategies, and redefinition.
作者信息
Manuel Robbie Sj, Vezina Chad M
机构信息
Department of Comparative Biosciences, University of Wisconsin-Madison Madison, WI 53706, USA.
Molecular and Environmental Toxicology Graduate Program, University of Wisconsin School of Medicine and Public Health Madison, WI 53705, USA.
出版信息
Am J Clin Exp Urol. 2024 Apr 15;12(2):52-63. doi: 10.62347/OUJJ3710. eCollection 2024.
Abstract
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPSS) is a debilitating condition characterized by prostate inflammation, pain and urinary symptoms. The immune system's response to self-antigens is a contributing factor to CP/CPSS. In this review, we examine the use of experimental autoimmune prostatitis (EAP) in rodents to model salient features of autoimmune mediated CP/CPSS. By exploring etiological factors, immunological mechanisms, and emerging therapeutic strategies, our aim is to enhance our understanding of CP/CPSS pathogenesis and promote the development of strategies to test innovative interventions using the EAP pre-clinical model.
摘要
慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPSS）是一种使人衰弱的病症，其特征为前列腺炎症、疼痛和泌尿系统症状。免疫系统对自身抗原的反应是CP/CPSS的一个促成因素。在本综述中，我们研究了在啮齿动物中使用实验性自身免疫性前列腺炎（EAP）来模拟自身免疫介导的CP/CPSS的显著特征。通过探索病因、免疫机制和新兴治疗策略，我们的目的是加深对CP/CPSS发病机制的理解，并促进使用EAP临床前模型测试创新干预措施的策略的发展。
相似文献
1
Trends in experimental autoimmune prostatitis: insights into pathogenesis, therapeutic strategies, and redefinition.实验性自身免疫性前列腺炎的研究趋势：对发病机制、治疗策略及重新定义的见解
Am J Clin Exp Urol. 2024 Apr 15;12(2):52-63. doi: 10.62347/OUJJ3710. eCollection 2024.
2
The aryl hydrocarbon receptor agonist ITE reduces inflammation and urinary dysfunction in a mouse model of autoimmune prostatitis.芳基烃受体激动剂ITE可减轻自身免疫性前列腺炎小鼠模型中的炎症和排尿功能障碍。
Am J Clin Exp Urol. 2024 Aug 25;12(4):149-161. doi: 10.62347/PEGK4888. eCollection 2024.
3
Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis.酒精对实验性自身免疫性前列腺炎小鼠模型中慢性盆腔疼痛和前列腺炎症的影响。
Prostate. 2019 Sep;79(12):1439-1449. doi: 10.1002/pros.23866. Epub 2019 Jun 24.
4
Experimental autoimmune prostatitis: different antigens induction and antigen-specific therapy.实验性自身免疫性前列腺炎：不同抗原诱导和抗原特异性治疗。
Int Urol Nephrol. 2021 Apr;53(4):607-618. doi: 10.1007/s11255-020-02703-8. Epub 2020 Nov 16.
5
Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO-1 pathway.丁酸钠通过Nrf2/HO-1途径抑制氧化应激和NLRP3炎性小体激活来减轻实验性自身免疫性前列腺炎。
Prostate. 2024 May;84(7):666-681. doi: 10.1002/pros.24683. Epub 2024 Mar 5.
6
Role of GM-CSF in a mouse model of experimental autoimmune prostatitis.粒细胞-巨噬细胞集落刺激因子在实验性自身免疫性前列腺炎小鼠模型中的作用。
Am J Physiol Renal Physiol. 2019 Jul 1;317(7):F23-F29. doi: 10.1152/ajprenal.00013.2018. Epub 2019 Apr 3.
7
Effect of Eriocalyxin B on prostatic inflammation and pelvic pain in a mouse model of experimental autoimmune prostatitis.Eriocalyxin B 对实验性自身免疫性前列腺炎小鼠模型中前列腺炎症和盆腔疼痛的影响。
Prostate. 2020 Dec;80(16):1394-1404. doi: 10.1002/pros.24065. Epub 2020 Sep 23.
8
Astaxanthin alleviates chronic prostatitis/chronic pelvic pain syndrome by increasing colonization of Akkermansia muciniphila in the intestine.虾青素通过增加肠道中产黏液阿克曼菌的定植缓解慢性前列腺炎/慢性骨盆疼痛综合征。
Phytomedicine. 2024 Jan;123:155249. doi: 10.1016/j.phymed.2023.155249. Epub 2023 Nov 25.
9
Immunological alterations in patients with chronic prostatitis/chronic pelvic pain syndrome and experimental autoimmune prostatitis model: A systematic review and meta-analysis.慢性前列腺炎/慢性盆腔疼痛综合征患者及实验性自身免疫性前列腺炎模型的免疫学改变：一项系统评价和荟萃分析。
Cytokine. 2021 May;141:155440. doi: 10.1016/j.cyto.2021.155440. Epub 2021 Feb 4.
10
TRPV1 in experimental autoimmune prostatitis.TRPV1 在实验性自身免疫性前列腺炎中的作用。
Prostate. 2020 Jan;80(1):28-37. doi: 10.1002/pros.23913. Epub 2019 Oct 1.
本文引用的文献
1
A review of current treatments for chronic prostatitis/chronic pelvic pain syndrome under the UPOINTS system.UPOINTS 系统下慢性前列腺炎/慢性骨盆疼痛综合征的现行治疗方法综述。
Int J Urol. 2023 May;30(5):431-436. doi: 10.1111/iju.15149. Epub 2023 Feb 14.
2
Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics.针对炎症、感染和癌症的TLR4治疗靶点：二糖脂A模拟物的前景
Pharmaceuticals (Basel). 2022 Dec 23;16(1):23. doi: 10.3390/ph16010023.
3
Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions.计算建模复杂的生物能量机制，调节 CD4+T 细胞效应和调节功能。
NPJ Syst Biol Appl. 2022 Nov 22;8(1):45. doi: 10.1038/s41540-022-00263-4.
4
Abnormal prostate microbiota composition is associated with experimental autoimmune prostatitis complicated with depression in rats.异常的前列腺微生物群落组成与实验性自身免疫性前列腺炎合并抑郁大鼠有关。
Front Cell Infect Microbiol. 2022 Sep 30;12:966004. doi: 10.3389/fcimb.2022.966004. eCollection 2022.
5
Evaluation of the Anti-Inflammatory and Chondroprotective Effect of Celecoxib on Cartilage and in a Rat Osteoarthritis Model.评估塞来昔布对软骨的抗炎和软骨保护作用及其在大鼠骨关节炎模型中的作用。
Cartilage. 2022 Jul-Sep;13(3):19476035221115541. doi: 10.1177/19476035221115541.
6
Tadalafil monotherapy in management of chronic prostatitis/chronic pelvic pain syndrome: a randomized double-blind placebo controlled clinical trial.他达拉非单药治疗慢性前列腺炎/慢性盆腔疼痛综合征：一项随机、双盲、安慰剂对照的临床研究。
World J Urol. 2022 Oct;40(10):2505-2511. doi: 10.1007/s00345-022-04074-4. Epub 2022 Jul 8.
7
TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease.肿瘤坏死因子（TNF）是一种潜在的治疗靶点，可抑制自身免疫性疾病中的前列腺炎症和增生。
Nat Commun. 2022 Apr 19;13(1):2133. doi: 10.1038/s41467-022-29719-1.
8
mMCP7, a Mouse Ortholog of δ Tryptase, Mediates Pelvic Tactile Allodynia in a Model of Chronic Pelvic Pain.mMCP7，一种δ胰蛋白酶的小鼠直系同源物，在慢性盆腔疼痛模型中介导盆腔触觉异常性疼痛。
Front Pain Res (Lausanne). 2022 Jan 12;2:805136. doi: 10.3389/fpain.2021.805136. eCollection 2021.
9
Pathogenic Roles of CXCL10 in Experimental Autoimmune Prostatitis by Modulating Macrophage Chemotaxis and Cytokine Secretion.CXCL10 在实验性自身免疫性前列腺炎中的致病作用通过调节巨噬细胞趋化和细胞因子分泌。
Front Immunol. 2021 Sep 29;12:706027. doi: 10.3389/fimmu.2021.706027. eCollection 2021.
10
Chronic Prostatitis and Pelvic Pain Syndrome: Another Autoimmune Disease?慢性前列腺炎和盆腔疼痛综合征：另一种自身免疫性疾病？
Arch Immunol Ther Exp (Warsz). 2021 Sep 14;69(1):24. doi: 10.1007/s00005-021-00628-3.
Zotero 插件