Chen Lei, Zhang Meng, Liang Chaozhao
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.
Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, 230022, People's Republic of China.
Arch Immunol Ther Exp (Warsz). 2021 Sep 14;69(1):24. doi: 10.1007/s00005-021-00628-3.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), characterized by chronic pain in the perineum or lower abdomen regions, is a frequent disorder in men. Previous studies demonstrated that the immune mediators, including interleukin (IL)-1β, IL-6, interferon-γ, tumor necrosis factor-α, and immunoglobulins, are elevated in the expressed prostate secretions and seminal fluid of CP/CPPS men. The memory T, T helper 1 (Th1), Th17, and Th22 cells increase in the peripheral blood of CP/CPPS men. Additionally, prostate antigens specific-autoreactive T cells are identified in CP/CPPS patients. After generally reviewing and comparing the inflammatory responses in autoimmune diseases and CP/CPPS, we presumed that CP/CPPS is more likely to be defined as an autoimmune disease. Thus, a better understanding of autoimmune diseases would contribute to a deeper understanding of the CP/CPPS and provide new inspirations for the treatment of this disease.
慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）以会阴区或下腹部慢性疼痛为特征，是男性的一种常见疾病。先前的研究表明，在CP/CPPS男性的前列腺分泌物和精液中，包括白细胞介素（IL）-1β、IL-6、干扰素-γ、肿瘤坏死因子-α和免疫球蛋白在内的免疫介质水平升高。CP/CPPS男性外周血中的记忆T细胞、辅助性T细胞1（Th1）、Th17和Th22细胞增加。此外，在CP/CPPS患者中鉴定出前列腺抗原特异性自身反应性T细胞。在对自身免疫性疾病和CP/CPPS中的炎症反应进行全面回顾和比较后，我们推测CP/CPPS更有可能被定义为一种自身免疫性疾病。因此，更好地了解自身免疫性疾病将有助于更深入地理解CP/CPPS，并为该疾病的治疗提供新的思路。
