Zwaans Bernadette Mm, Mota Sabrina, Bartolone Sarah N, Ward Elijah P, Peters Kenneth M, Chancellor Michael B
Oakland University William Beaumont School of Medicine Rochester, MI, USA.
Corewell Health William Beaumont University Hospital Royal Oak, MI, USA.
Am J Clin Exp Urol. 2024 Apr 15;12(2):110-118. doi: 10.62347/BLED2401. eCollection 2024.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a condition characterized in part by urinary urgency, frequency, and pain. There is a strong interest in gathering more data to compare and assess the differences in characteristics based on the presence of Hunner's lesions in patients with IC/BPS.
Using a nationwide crowdsource effort, we collected surveys and urine samples from patients with a history of IC/BPS. Participants completed the Interstitial Cystitis Symptom Index (ICSI) and Problem Index (ICPI), Overactive Bladder questionnaire (OABq SF), and pain scores. In addition, participants reported any co-morbidities and lifestyle modifications. Urinary cytokine levels were measured and compared to symptom severity.
491 participants enrolled: 119 with history of ulcerative Hunner's lesions (UIC), 372 reported no lesions (NHIC), and 2 unknowns. 96.3% were female, and prevalence of UIC was equal for both genders. Average age was higher for UIC vs. NHIC group (P = 0.011), as was the duration since diagnosis (P < 0.001). Symptom scores were elevated in UIC patients (P < 0.001). Both groups widely implemented lifestyle modifications, with dietary changes being most prevalent (70.1%), followed by prescription medication usage (63.1%). More UIC compared to NHIC participants experienced co-morbidities (P = 0.010). Urine samples were analyzed for GRO, IL-6, IL-8, and MCP-1. MCP-1 levels were significantly higher in UIC patients (P = 0.044). Weak positive correlation was found between cytokines and symptom scores.
Patients with UIC and NHIC from across the United States displayed distinct phenotypic and urine biological characteristics. These findings contribute to increased understanding of IC/BPS and may aid in improving our knowledge of the condition.
间质性膀胱炎/膀胱疼痛综合征（IC/BPS）是一种部分特征为尿急、尿频和疼痛的病症。人们对收集更多数据以比较和评估基于IC/BPS患者中是否存在Hunner病变的特征差异有着浓厚兴趣。
通过全国范围的众包努力，我们收集了有IC/BPS病史患者的调查问卷和尿液样本。参与者完成了间质性膀胱炎症状指数（ICSI）和问题指数（ICPI）、膀胱过度活动症问卷（OABq SF）以及疼痛评分。此外，参与者报告了任何合并症和生活方式的改变。测量尿液细胞因子水平并与症状严重程度进行比较。
491名参与者入组：119名有溃疡性Hunner病变病史（UIC），372名报告无病变（NHIC），2名情况不明。96.3%为女性，UIC在两性中的患病率相同。UIC组的平均年龄高于NHIC组（P = 0.011），诊断后的病程也是如此（P < 0.001）。UIC患者的症状评分升高（P < 0.001）。两组都广泛采取了生活方式的改变，饮食改变最为普遍（70.1%），其次是使用处方药（63.1%）。与NHIC参与者相比，更多的UIC参与者患有合并症（P = 0.010）。对尿液样本进行了GRO、IL-6、IL-8和MCP-1分析。UIC患者的MCP-1水平显著更高（P = 0.044）。细胞因子与症状评分之间存在弱正相关。
来自美国各地的UIC和NHIC患者表现出不同的表型和尿液生物学特征。这些发现有助于加深对IC/BPS的理解，并可能有助于提高我们对该病症的认识。
