Laurent J, Belghiti D, Ansquer J C, Cambon-Thomsen A, Bracq C, Reinert P, Lagrue G
Rev Med Interne. 1985 Mar;6(2):116-20. doi: 10.1016/s0248-8663(85)80055-2.
High prevalence of HLA DR7 was well documented in idiopathic nephrotic syndrome (INS) of childhood. Our data in 43 INS, child and adult patients, did not show any significant difference from control group, specially for HLA DR7. Moreover a significant difference occurred when the data was compared in child and adult INS patients. HLA DR7 was more frequent when the nephrotic syndrome appeared before 15 years old. There was no correlation between the presence of HLA DR7 and those of allergy history or increased serum IgE level, on the opposite with previous data. The presence of DR7 would favor its onset at an earlier age. Alternatively, the difference in DR7 prevalence could be an additional argument for considering that the corticosensitivity and negative histological criteria might collect, under the same name, different glomerulopathies.
HLA DR7在儿童特发性肾病综合征（INS）中的高患病率已有充分记载。我们对43例INS患儿及成年患者的数据研究显示，与对照组相比无显著差异，尤其是HLA DR7。此外，对儿童和成年INS患者的数据进行比较时出现了显著差异。肾病综合征在15岁之前出现时，HLA DR7更为常见。与既往数据相反，HLA DR7的存在与过敏史或血清IgE水平升高之间没有相关性。DR7的存在可能有助于其在较早年龄发病。或者，DR7患病率的差异可能是一个额外的论据，支持皮质敏感性和阴性组织学标准可能在同一名称下涵盖不同肾小球病的观点。
