Schneider Alan L
Department of Psychiatry, Keck School of Medicine, University of Southern California, Newport Beach, CA, United States.
J Family Med Prim Care. 2024 Mar;13(3):1103-1105. doi: 10.4103/jfmpc.jfmpc_645_23. Epub 2024 Apr 4.
This is a report of a series of three cases of trazodone-induced oral lingual dyskinesias. Each case demonstrated a distinct pattern of the development of this dyskinesia after trazodone exposure for several months. All cases showed abrupt cessation of the movement disorder when the drug was discontinued. Two of the three cases had no prior exposure to any dopamine-blocking agents. One of the three had a distant exposure to a dopamine antagonist. Trazodone has a mechanism of action that can account for both the development and treatment of dyskinetic movements. This article will discuss proposed mechanisms for trazodone's action with an emphasis on case reports of dystonic movements being more prevalent in the elderly.
这是一篇关于三例曲唑酮诱发口腔舌运动障碍的系列病例报告。每例病例均显示在服用曲唑酮数月后出现这种运动障碍的独特发展模式。所有病例在停药后运动障碍均突然停止。三例病例中有两例此前未接触过任何多巴胺阻断剂。三例中有一例曾在很久以前接触过多巴胺拮抗剂。曲唑酮的作用机制可以解释运动障碍的发生和治疗。本文将讨论曲唑酮作用的推测机制，重点是肌张力障碍性运动在老年人中更为普遍的病例报告。
