Tanaka Hidekazu
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine Kobe Japan.
Circ Rep. 2024 Apr 19;6(5):183-186. doi: 10.1253/circrep.CR-24-0034. eCollection 2024 May 10.
Elevations of resting heart rate (HR) in patients with heart failure (HF) with reduced ejection fraction (HFrEF) are often missed, resulting in some patients with an indication for ivabradine reportedly being missed. We studied 30 relatively stable HFrEF outpatients, and ivabradine was administered when regular follow-up echocardiography showed a resting HR ≥75 beats/min. Significant left ventricular reverse remodeling was observed 10.1±3.9 months after administration of ivabradine. This finding may well make this procedure a potential new approach for preventing worsening of HF for relatively stable patients with HFrEF.
射血分数降低的心力衰竭（HFrEF）患者静息心率（HR）升高的情况常常被漏诊，导致一些据报道有使用伊伐布雷定指征的患者被漏诊。我们研究了30例相对稳定的HFrEF门诊患者，当常规随访超声心动图显示静息心率≥75次/分钟时给予伊伐布雷定。在给予伊伐布雷定10.1±3.9个月后观察到显著的左心室逆向重构。这一发现很可能使该方法成为预防相对稳定的HFrEF患者心力衰竭恶化的一种潜在新方法。
