Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China.
Department of Traditional Chinese Medicine, Cangzhou Central Hospital, Cangzhou, China.
Front Immunol. 2024 Apr 26;15:1383263. doi: 10.3389/fimmu.2024.1383263. eCollection 2024.
Acne vulgaris is one of the most common skin diseases. The current understanding of acne primarily revolves around inflammatory responses, sebum metabolism disorders, aberrant hormone and receptor expression, colonization by , and abnormal keratinization of follicular sebaceous glands. Although the precise mechanism of action remains incompletely understood, it is plausible that macrophages exert an influence on these pathological features. Macrophages, as a constituent of the human innate immune system, typically manifest distinct phenotypes across various diseases. It has been observed that the polarization of macrophages toward the M1 phenotype plays a pivotal role in the pathogenesis of acne. In recent years, extensive research on acne has revealed an increasing number of natural remedies exhibiting therapeutic efficacy through the modulation of macrophage polarization. This review investigates the role of cutaneous macrophages, elucidates their potential significance in the pathogenesis of acne, a prevalent chronic inflammatory skin disorder, and explores the therapeutic mechanisms of natural plant products targeting macrophages. Despite these insights, the precise role of macrophages in the pathogenesis of acne remains poorly elucidated. Subsequent investigations in this domain will further illuminate the pathogenesis of acne and potentially offer guidance for identifying novel therapeutic targets for this condition.
寻常痤疮是最常见的皮肤病之一。目前对痤疮的认识主要集中在炎症反应、皮脂代谢紊乱、激素和受体表达异常、定植和毛囊皮脂腺角质化异常。虽然确切的作用机制尚不完全清楚，但巨噬细胞对这些病理特征有影响是合理的。巨噬细胞作为人体先天免疫系统的一部分，在各种疾病中表现出不同的表型。已经观察到，巨噬细胞向 M1 表型的极化在痤疮的发病机制中起着关键作用。近年来，对痤疮的广泛研究揭示了越来越多的天然药物通过调节巨噬细胞极化显示出治疗效果。本综述探讨了皮肤巨噬细胞的作用，阐明了它们在寻常痤疮这一常见的慢性炎症性皮肤病发病机制中的潜在意义，并探讨了针对巨噬细胞的天然植物产物的治疗机制。尽管有这些发现，但巨噬细胞在痤疮发病机制中的确切作用仍不清楚。该领域的后续研究将进一步阐明痤疮的发病机制，并可能为确定该疾病的新治疗靶点提供指导。
