Department of Dermatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Immunol. 2024 Mar 14;15:1355455. doi: 10.3389/fimmu.2024.1355455. eCollection 2024.
Macrophages serve as a pivotal nexus in the pathogenesis of acne vulgaris, orchestrating both the elimination of () and lipid metabolic regulation while also possessing the capacity to exacerbate inflammation and induce cutaneous scarring. Additionally, recent investigations underscore the therapeutic potential inherent in macrophage modulation and challenge current anti-inflammatory strategies for acne vulgaris. This review distills contemporary advances, specifically examining the dual roles of macrophages, underlying regulatory frameworks, and emergent therapeutic avenues. Such nuanced insights hold the promise of guiding future explorations into the molecular etiology of acne and the development of more efficacious treatment modalities.
巨噬细胞在寻常痤疮的发病机制中起着关键的枢纽作用，既能清除 ()，又能调节脂质代谢，同时还具有加重炎症和诱导皮肤瘢痕形成的能力。此外，最近的研究强调了巨噬细胞调节的治疗潜力，挑战了目前治疗寻常痤疮的抗炎策略。本综述总结了当前的进展，特别考察了巨噬细胞的双重作用、潜在的调控机制以及新兴的治疗途径。这些细致的见解有望指导未来对痤疮分子病因学的探索和更有效的治疗方法的发展。
