类风湿因子阳性健康人群中HLA - DR4和HLA - DR3的患病率

The prevalence of HLA-DR4 and HLA-DR3 in healthy persons with rheumatoid factor.

作者信息

Gran J T, Husby G, Thorsby E

出版信息

Scand J Rheumatol. 1985;14(1):79-82. doi: 10.3109/03009748509102024.

DOI:10.3109/03009748509102024

Abstract

The frequency of the HLA antigen DR4 has been determined in healthy individuals with serum IgM RF. HLA DR4 was found in 11.6% of these persons as compared with 27% in healthy controls. Thus, no association between IgM RF and HLA-DR4 could be found in this material of healthy individuals. HLA-DR3 was found in 35% of healthy RF-positive persons, which was no different from the 30% prevalence among healthy controls. HLA-DR3 did not seem to be associated with high immune responsiveness of RF in RF-positive individuals.

摘要

已在患有血清 IgM 类风湿因子（RF）的健康个体中测定了 HLA 抗原 DR4 的频率。在这些人中，发现 HLA DR4 的比例为 11.6%，而健康对照者中的比例为 27%。因此，在这些健康个体材料中未发现 IgM RF 与 HLA - DR4 之间存在关联。在 35%的健康 RF 阳性个体中发现了 HLA - DR3，这与健康对照者中 30%的患病率没有差异。HLA - DR3 似乎与 RF 阳性个体中 RF 的高免疫反应性无关。