Gran J T, Husby G, Thorsby E
Ann Rheum Dis. 1983 Jun;42(3):292-6. doi: 10.1136/ard.42.3.292.
One hundred and forty-two patients with 'definite' or 'classical' rheumatoid arthritis (RA) were studied for the frequency and possible prognostic significance of HLA DR4. Of these, 122 were seropositive, while 20 were negative for rheumatoid factor (RF) in serum. The HLA antigen DR4 was significantly increased in the seropositive group (65%) as well as in the seronegative group (55%) in comparison with a frequency of 27% in 116 healthy controls. Among seropositive patients a higher frequency of DR4 was found in females (73%) than in males (50%), the difference being statistically significant (p less than 0.01). DR4 was more frequent among patients with a family history of RA (74%) than among patients without affected relatives (57%). DR4 appeared to be associated with an early onset of RA. No significant differences in general disease activity or functional capacity between DR4-positive and DR4-negative RA patients were found. Patients without the HLA antigen DR4 had a significantly (p less than 0.05) higher mean titre of RF than those with the antigen.
对142例患有“明确”或“典型”类风湿性关节炎（RA）的患者进行了研究，以探讨HLA DR4的出现频率及其可能的预后意义。其中，122例血清学呈阳性，20例血清类风湿因子（RF）呈阴性。与116名健康对照者中27%的出现频率相比，血清学阳性组（65%）和血清学阴性组（55%）中HLA抗原DR4的比例均显著升高。在血清学阳性患者中，女性DR4的出现频率（73%）高于男性（50%），差异具有统计学意义（p<0.01）。有类风湿性关节炎家族史的患者中DR4出现频率（74%）高于无患病亲属的患者（57%）。DR4似乎与类风湿性关节炎的早发有关。未发现DR4阳性和DR4阴性类风湿性关节炎患者在总体疾病活动度或功能能力方面存在显著差异。无HLA抗原DR4的患者的RF平均滴度显著高于（p<0.05）有该抗原的患者。
