Wüst J
Schweiz Med Wochenschr. 1985 Apr 20;115(16):555-7.
There are numerous reports on resistance or decreased susceptibility of pneumococci to penicillin. Recently, two strains of Streptococcus pneumoniae were isolated for the first time in Zurich with minimal inhibitory concentrations of 0.25 and 1.0 mg penicillin G per liter, respectively. One strain was also resistant to chloramphenicol and tetracycline; both isolates were resistant to sulfamethoxazole/trimethoprim. In view of this emergent resistance, routine susceptibility testing of clinically significant pneumococci is to be recommended. However, in the agar diffusion test the use of a penicillin disk may produce false-susceptible results, and therefore the susceptibility test should be performed with a disk containing oxacillin.
关于肺炎球菌对青霉素耐药或敏感性降低的报道众多。最近，苏黎世首次分离出两株肺炎链球菌，其对青霉素G的最低抑菌浓度分别为每升0.25毫克和1.0毫克。其中一株还对氯霉素和四环素耐药；两株分离株均对磺胺甲恶唑/甲氧苄啶耐药。鉴于这种新出现的耐药性，建议对具有临床意义的肺炎球菌进行常规药敏试验。然而，在琼脂扩散试验中，使用青霉素纸片可能会产生假敏感结果，因此药敏试验应使用含苯唑西林的纸片进行。
